Chlorine in PDB 6ech: Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp

Enzymatic activity of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp

All present enzymatic activity of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp:
2.7.1.40;

Protein crystallography data

The structure of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp, PDB code: 6ech was solved by A.Padyana, S.Tong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.52 / 2.19
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 86.550, 108.900, 296.840, 90.00, 90.00, 90.00
R / Rfree (%) 18.1 / 23.8

Other elements in 6ech:

The structure of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp also contains other interesting chemical elements:

Magnesium (Mg) 13 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp (pdb code 6ech). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp, PDB code: 6ech:

Chlorine binding site 1 out of 1 in 6ech

Go back to Chlorine Binding Sites List in 6ech
Chlorine binding site 1 out of 1 in the Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Pyruvate Kinase Isoform L-Type with Phosphorylated SER12 (PS12) in Complex with Fbp within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl616

b:62.6
occ:1.00
 O D:HOH989 3.3 57.6 1.0
N D:GLY212 3.5 44.0 1.0
O C:HOH915 3.8 52.1 1.0
CA D:HIS211 4.0 51.2 1.0
O D:GLY212 4.1 45.3 1.0
CZ C:PHE382 4.1 43.6 1.0
C D:HIS211 4.2 48.5 1.0
CD D:LYS148 4.3 62.3 1.0
CA D:GLY212 4.3 42.8 1.0
ND1 D:HIS211 4.4 59.7 1.0
CB D:HIS211 4.4 51.9 1.0
CB D:LYS148 4.4 56.2 1.0
C D:GLY212 4.5 42.4 1.0
CG D:LYS148 4.7 56.8 1.0
CE2 C:PHE382 4.8 46.1 1.0
O D:GLU210 4.9 54.1 1.0
CG D:HIS211 4.9 54.9 1.0

Reference:

B.M.Gassaway, R.L.Cardone, A.K.Padyana, M.C.Petersen, E.T.Judd, S.Hayes, S.Tong, K.W.Barber, M.Apostolidi, A.Abulizi, J.B.Sheetz, G.Kshitiz, H.R.Aerni, S.Gross, C.Kung, V.T.Samuel, G.I.Shulman, R.G.Kibbey, J.Rinehart. Distinct Hepatic Pka and Cdk Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Rep 2019.
ISSN: ESSN 2211-1247
Page generated: Sat Dec 12 12:55:10 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy