Chlorine in PDB 6ezc: Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Catalytic Domain E294K Q305K Double Mutant

Protein crystallography data

The structure of Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Catalytic Domain E294K Q305K Double Mutant, PDB code: 6ezc was solved by C.Bou-Nader, D.Bregeon, G.Vincent, M.Fontecave, D.Hamdane, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.33 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 45.990, 84.660, 100.390, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 22.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Catalytic Domain E294K Q305K Double Mutant (pdb code 6ezc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Catalytic Domain E294K Q305K Double Mutant, PDB code: 6ezc:

Chlorine binding site 1 out of 1 in 6ezc

Go back to Chlorine Binding Sites List in 6ezc
Chlorine binding site 1 out of 1 in the Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Catalytic Domain E294K Q305K Double Mutant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Catalytic Domain E294K Q305K Double Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl405

b:49.7
occ:1.00
O A:HOH582 2.9 34.2 1.0
NE A:ARG157 3.4 53.8 1.0
ND1 A:HIS183 3.4 37.4 1.0
NH2 A:ARG157 3.7 48.7 1.0
NZ A:LYS155 3.7 35.7 1.0
O A:GLY115 3.7 81.4 1.0
C A:GLY115 3.8 0.2 1.0
CZ A:ARG157 4.0 62.3 1.0
C1' A:FMN401 4.0 26.9 1.0
CA A:GLY115 4.0 79.6 1.0
C3 A:GOL406 4.1 35.1 0.6
O3' A:FMN401 4.1 27.3 1.0
C3 A:GOL406 4.1 37.6 0.4
CE1 A:HIS183 4.1 37.5 1.0
O A:HOH693 4.2 52.2 1.0
N1 A:FMN401 4.2 26.1 1.0
CG A:ARG157 4.3 44.3 1.0
O3 A:GOL406 4.4 34.4 0.6
CD A:ARG157 4.4 54.3 1.0
CG A:HIS183 4.5 36.3 1.0
O2 A:GOL406 4.6 37.2 0.4
O3 A:GOL406 4.7 36.3 0.4
N10 A:FMN401 4.8 26.7 1.0
CB A:HIS183 4.8 32.9 1.0
C10 A:FMN401 4.9 26.3 1.0
C2 A:GOL406 4.9 37.0 0.4
O A:HOH591 5.0 38.1 1.0

Reference:

C.Bou-Nader, D.Bregeon, L.Pecqueur, M.Fontecave, D.Hamdane. Electrostatic Potential in the Trna Binding Evolution of Dihydrouridine Synthases. Biochemistry V. 57 5407 2018.
ISSN: ISSN 1520-4995
PubMed: 30149704
DOI: 10.1021/ACS.BIOCHEM.8B00584
Page generated: Sat Dec 12 12:56:47 2020

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