Chlorine in PDB 6ezo: Eukaryotic Initiation Factor EIF2B in Complex with Isrib

The binding sites of Chlorine atom in the Eukaryotic Initiation Factor EIF2B in Complex with Isrib (pdb code 6ezo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Eukaryotic Initiation Factor EIF2B in Complex with Isrib, PDB code: 6ezo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Eukaryotic Initiation Factor EIF2B in Complex with Isrib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Eukaryotic Initiation Factor EIF2B in Complex with Isrib within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:66.0 occ:1.00 CL1 D:C7B401 0.0 66.0 1.0 C29 D:C7B401 1.7 66.0 1.0 C27 D:C7B401 2.7 66.0 1.0 C25 D:C7B401 2.7 66.5 1.0 CD1 C:ILE190 3.5 25.2 1.0 CG2 C:VAL225 3.7 26.1 1.0 CG1 C:VAL225 3.7 26.7 1.0 C23 D:C7B401 4.0 66.2 1.0 C21 D:C7B401 4.0 66.8 1.0 CG1 C:ILE190 4.2 24.8 1.0 CG2 C:ILE190 4.3 25.3 1.0 CB C:VAL225 4.3 26.2 1.0 OG1 C:THR215 4.4 29.2 1.0 C19 D:C7B401 4.5 65.9 1.0 CB C:ILE190 4.9 25.0 1.0

Chlorine binding site 2 out of 2 in the Eukaryotic Initiation Factor EIF2B in Complex with Isrib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Eukaryotic Initiation Factor EIF2B in Complex with Isrib within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:73.4 occ:1.00 CL2 D:C7B401 0.0 73.4 1.0 C30 D:C7B401 1.7 72.8 1.0 C28 D:C7B401 2.7 72.1 1.0 C26 D:C7B401 2.7 73.6 1.0 CG2 D:VAL225 3.5 18.1 1.0 C24 D:C7B401 4.0 73.5 1.0 C22 D:C7B401 4.0 73.2 1.0 CG1 D:VAL225 4.0 18.3 1.0 CZ H:PHE452 4.2 31.9 1.0 CB D:VAL225 4.3 18.1 1.0 CD1 D:ILE190 4.4 28.4 1.0 CE1 H:PHE452 4.4 32.1 1.0 C20 D:C7B401 4.5 72.7 1.0

A.F.Zyryanova, F.Weis, A.Faille, A.A.Alard, A.Crespillo-Casado, Y.Sekine, H.P.Harding, F.Allen, L.Parts, C.Fromont, P.M.Fischer, A.J.Warren, D.Ron. Binding of Isrib Reveals A Regulatory Site in the Nucleotide Exchange Factor EIF2B. Science V. 359 1533 2018.
ISSN: ESSN 1095-9203
PubMed: 29599245
DOI: 10.1126/SCIENCE.AAR5129