Chlorine in PDB 6f3t: Crystal Structure of the Human TAF5-TAF6-TAF9 Complex

The structure of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex, PDB code: 6f3t was solved by M.Haffke, I.Berger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	79.92 / 2.50
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	339.050, 339.050, 339.050, 90.00, 90.00, 90.00
R / Rfree (%)	19.7 / 22

The binding sites of Chlorine atom in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex (pdb code 6f3t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex, PDB code: 6f3t:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl901 b:73.1 occ:1.00 H A:TYR598 2.4 87.5 1.0 HD2 A:TYR557 3.1 74.8 1.0 O A:HOH1052 3.1 60.5 1.0 N A:TYR598 3.2 73.1 1.0 HA3 A:GLY597 3.3 85.4 1.0 HE2 A:TYR557 3.3 79.0 1.0 HB2 A:SER552 3.5 88.2 1.0 HE1 A:PHE593 3.7 81.1 1.0 HA2 A:GLY597 3.7 85.4 1.0 HA A:TYR598 3.8 84.8 1.0 CD2 A:TYR557 3.8 62.6 1.0 CA A:GLY597 3.8 71.4 1.0 CE2 A:TYR557 3.9 66.0 1.0 CE1 A:PHE593 4.0 67.8 1.0 C A:GLY597 4.1 70.0 1.0 CA A:TYR598 4.1 70.8 1.0 HB3 A:SER552 4.2 88.2 1.0 CB A:SER552 4.3 73.7 1.0 HD2 A:PRO553 4.3 84.5 1.0 HG21 A:THR614 4.3 74.3 1.0 HZ A:PHE593 4.3 80.5 1.0 OD2 A:ASP554 4.4 90.1 1.0 CZ A:PHE593 4.4 67.3 1.0 HG A:SER552 4.4 85.3 1.0 OD1 A:ASP554 4.5 92.3 1.0 CD1 A:PHE593 4.7 64.8 1.0 CG A:ASP554 4.7 89.3 1.0 HB2 A:TYR598 4.8 78.7 1.0 HD1 A:PHE593 4.8 77.5 1.0 OG A:SER552 4.8 71.3 1.0 HB2 A:TYR557 5.0 72.9 1.0

Chlorine binding site 2 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl902 b:0.8 occ:1.00 O A:TRP589 2.8 70.9 1.0 HE1 E:MET60 2.9 0.9 1.0 O A:TYR547 2.9 68.1 1.0 CE E:MET60 3.5 88.5 1.0 HE3 E:MET60 3.5 0.9 1.0 HE2 E:MET60 3.5 0.9 1.0 HZ1 E:LYS62 3.6 0.6 1.0 HB3 A:TYR547 3.6 71.0 1.0 HB2 A:ASP590 3.8 80.3 1.0 HA A:ASP590 4.0 74.2 1.0 C A:TRP589 4.0 61.7 1.0 C A:TYR547 4.0 63.2 1.0 OD1 A:ASP590 4.2 77.1 1.0 HB3 A:TRP589 4.3 75.1 1.0 NZ E:LYS62 4.4 0.8 1.0 HA2 A:GLY548 4.4 70.1 1.0 CB A:ASP590 4.4 67.1 1.0 CG A:ASP590 4.4 72.9 1.0 O A:ASN631 4.4 59.1 1.0 HZ3 E:LYS62 4.4 0.6 1.0 CB A:TYR547 4.5 59.3 1.0 HE2 E:LYS62 4.5 0.3 1.0 CA A:ASP590 4.5 62.0 1.0 HA A:TYR547 4.7 71.8 1.0 CA A:TYR547 4.7 60.0 1.0 N A:ASP590 4.7 60.1 1.0 HB2 A:TYR547 4.8 71.0 1.0 HA A:TRP589 4.9 71.8 1.0 N A:GLY548 4.9 60.2 1.0 CE E:LYS62 4.9 98.8 1.0 CA A:TRP589 4.9 60.0 1.0 HZ2 E:LYS62 5.0 0.6 1.0 CA A:GLY548 5.0 58.6 1.0

Chlorine binding site 3 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl901 b:73.5 occ:1.00 H B:TYR598 2.4 83.3 1.0 HD2 B:TYR557 3.1 74.2 1.0 O B:HOH1031 3.1 59.0 1.0 HE2 B:TYR557 3.2 81.5 1.0 N B:TYR598 3.3 69.6 1.0 HA3 B:GLY597 3.3 87.8 1.0 HB2 B:SER552 3.5 89.1 1.0 CD2 B:TYR557 3.7 62.0 1.0 HA2 B:GLY597 3.7 87.8 1.0 HA B:TYR598 3.8 77.2 1.0 HE1 B:PHE593 3.8 76.7 1.0 CE2 B:TYR557 3.8 68.1 1.0 CA B:GLY597 3.8 73.4 1.0 C B:GLY597 4.1 73.0 1.0 CA B:TYR598 4.1 64.5 1.0 CE1 B:PHE593 4.2 64.1 1.0 HB3 B:SER552 4.2 89.1 1.0 CB B:SER552 4.3 74.5 1.0 HG21 B:THR614 4.3 81.3 1.0 OD2 B:ASP554 4.3 85.0 1.0 HD2 B:PRO553 4.3 88.0 1.0 HG B:SER552 4.4 91.9 1.0 OD1 B:ASP554 4.4 87.9 1.0 HZ B:PHE593 4.5 76.3 1.0 CZ B:PHE593 4.6 63.8 1.0 O B:HOH1024 4.6 55.8 1.0 HB2 B:TYR598 4.7 76.2 1.0 CG B:ASP554 4.7 84.9 1.0 OG B:SER552 4.8 76.8 1.0 CD1 B:PHE593 4.9 61.6 1.0 HZ3 B:LYS433 4.9 0.5 1.0 HZ1 B:LYS433 4.9 0.5 1.0 HB2 B:TYR557 5.0 67.6 1.0

Chlorine binding site 4 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl901 b:71.4 occ:1.00 H C:TYR598 2.5 80.4 1.0 HD2 C:TYR557 3.1 73.2 1.0 HE2 C:TYR557 3.1 75.7 1.0 O C:HOH1082 3.1 49.2 1.0 HA3 C:GLY597 3.3 65.0 1.0 N C:TYR598 3.3 67.2 1.0 HB2 C:SER552 3.5 75.0 1.0 O C:HOH1105 3.6 59.3 1.0 HA2 C:GLY597 3.7 65.0 1.0 CD2 C:TYR557 3.7 61.2 1.0 HE1 C:PHE593 3.8 60.5 1.0 CE2 C:TYR557 3.8 63.3 1.0 CA C:GLY597 3.9 54.4 1.0 HA C:TYR598 3.9 74.3 1.0 CE1 C:PHE593 4.1 50.7 1.0 C C:GLY597 4.1 60.0 1.0 HB3 C:SER552 4.2 75.0 1.0 CA C:TYR598 4.2 62.1 1.0 CB C:SER552 4.3 62.7 1.0 HG21 C:THR614 4.3 64.5 1.0 OD2 C:ASP554 4.3 79.2 1.0 O J:HOH218 4.4 52.8 1.0 HD2 C:PRO553 4.4 73.2 1.0 OD1 C:ASP554 4.4 83.0 1.0 HZ C:PHE593 4.4 61.8 1.0 CZ C:PHE593 4.5 51.7 1.0 CG C:ASP554 4.7 78.1 1.0 OG C:SER552 4.8 63.1 1.0 CD1 C:PHE593 4.8 50.6 1.0 HB2 C:TYR598 4.8 63.8 1.0 O C:HOH1029 4.8 53.2 1.0 HZ1 C:LYS433 4.8 0.6 1.0 HZ3 C:LYS433 4.9 0.6 1.0 HD1 C:PHE593 4.9 60.5 1.0 HB2 C:TYR557 5.0 66.4 1.0

Chlorine binding site 5 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl902 b:76.2 occ:1.00 H C:ASN468 2.4 78.0 1.0 H G:GLU90 2.5 86.6 1.0 O C:HOH1058 2.6 53.4 1.0 HA C:ASN468 2.8 78.5 1.0 HE22 G:GLN89 3.0 77.7 1.0 HA G:GLN89 3.1 74.9 1.0 N C:ASN468 3.2 65.2 1.0 HE1 G:HIS87 3.2 92.7 1.0 NE2 G:GLN89 3.3 65.0 1.0 N G:GLU90 3.3 72.4 1.0 CA C:ASN468 3.4 65.6 1.0 HB3 G:GLU90 3.4 95.6 1.0 HE21 G:GLN89 3.6 77.7 1.0 HB2 G:GLU90 3.6 95.6 1.0 CD G:GLN89 3.7 63.4 1.0 HE2 G:HIS87 3.7 93.4 1.0 HB2 C:ASN468 3.8 75.0 1.0 OE1 G:GLN89 3.9 67.0 1.0 HZ3 H:LYS10 3.9 0.2 1.0 CE1 G:HIS87 3.9 77.4 1.0 CB G:GLU90 3.9 79.8 1.0 O G:ALA88 3.9 65.0 1.0 CA G:GLN89 4.0 62.7 1.0 NE2 G:HIS87 4.1 78.0 1.0 CB C:ASN468 4.1 62.7 1.0 O C:THR465 4.2 54.8 1.0 C G:GLN89 4.2 67.3 1.0 CA G:GLU90 4.2 71.2 1.0 H C:LEU467 4.3 74.4 1.0 C C:LEU467 4.4 62.3 1.0 HA C:LEU467 4.4 77.4 1.0 HD3 H:LYS10 4.5 0.2 1.0 H C:ALA469 4.5 81.5 1.0 O G:HOH101 4.5 63.3 1.0 OD1 C:ASN468 4.5 67.8 1.0 HG1 C:THR465 4.6 78.7 1.0 N C:LEU467 4.6 62.2 1.0 O G:GLU90 4.7 67.2 1.0 C C:ASN468 4.7 67.3 1.0 CG G:GLN89 4.7 64.0 1.0 HG3 G:GLN89 4.7 76.5 1.0 CA C:LEU467 4.7 64.7 1.0 NZ H:LYS10 4.7 0.4 1.0 CG C:ASN468 4.8 65.2 1.0 C G:ALA88 4.8 63.1 1.0 CB G:GLN89 4.9 62.1 1.0 HE2 H:LYS10 4.9 0.5 1.0 N C:ALA469 4.9 68.1 1.0 N G:GLN89 4.9 66.3 1.0 HB3 C:ASN468 5.0 75.0 1.0 C G:GLU90 5.0 68.7 1.0 HA G:GLU90 5.0 85.2 1.0

Chlorine binding site 6 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl901 b:70.9 occ:1.00 H D:TYR598 2.4 75.0 1.0 O D:HOH1061 3.1 51.9 1.0 HD2 D:TYR557 3.2 77.0 1.0 HA3 D:GLY597 3.2 71.8 1.0 N D:TYR598 3.2 62.7 1.0 HE2 D:TYR557 3.4 79.3 1.0 O D:HOH1046 3.4 70.5 1.0 HB2 D:SER552 3.6 71.7 1.0 HA2 D:GLY597 3.7 71.8 1.0 HA D:TYR598 3.8 75.8 1.0 HE1 D:PHE593 3.8 70.1 1.0 CA D:GLY597 3.8 60.1 1.0 CD2 D:TYR557 3.8 64.3 1.0 CE2 D:TYR557 3.9 66.3 1.0 C D:GLY597 4.0 60.0 1.0 CA D:TYR598 4.1 63.3 1.0 CE1 D:PHE593 4.2 58.6 1.0 HG21 D:THR614 4.3 67.7 1.0 HB3 D:SER552 4.3 71.7 1.0 CB D:SER552 4.4 60.0 1.0 O L:HOH210 4.4 55.7 1.0 HD2 D:PRO553 4.4 83.6 1.0 OD2 D:ASP554 4.5 77.3 1.0 HG D:SER552 4.5 74.2 1.0 HZ D:PHE593 4.5 62.3 1.0 OD1 D:ASP554 4.6 78.2 1.0 CZ D:PHE593 4.6 52.1 1.0 HB2 D:TYR598 4.7 72.4 1.0 O D:HOH1037 4.7 59.1 1.0 CG D:ASP554 4.8 76.2 1.0 CD1 D:PHE593 4.9 58.4 1.0 OG D:SER552 4.9 62.0 1.0 HZ3 D:LYS433 4.9 0.5 1.0 HD1 D:PHE593 5.0 69.8 1.0 HB2 D:TYR557 5.0 71.1 1.0

Chlorine binding site 7 out of 7 in the Crystal Structure of the Human TAF5-TAF6-TAF9 Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of the Human TAF5-TAF6-TAF9 Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl902 b:83.9 occ:1.00 H E:GLU90 2.4 82.5 1.0 H D:ASN468 2.4 70.4 1.0 HA D:ASN468 2.7 72.7 1.0 O D:HOH1012 3.0 62.2 1.0 HA E:GLN89 3.1 71.7 1.0 HE22 E:GLN89 3.1 74.0 1.0 N D:ASN468 3.2 58.9 1.0 N E:GLU90 3.2 68.9 1.0 HE1 E:HIS87 3.2 93.1 1.0 NE2 E:GLN89 3.3 61.9 1.0 HB3 E:GLU90 3.3 92.5 1.0 CA D:ASN468 3.4 60.8 1.0 HB2 E:GLU90 3.5 92.5 1.0 HE21 E:GLN89 3.6 74.0 1.0 CD E:GLN89 3.7 61.8 1.0 CB E:GLU90 3.8 77.2 1.0 HB2 D:ASN468 3.8 69.3 1.0 OE1 E:GLN89 3.9 63.8 1.0 CA E:GLN89 3.9 59.9 1.0 O E:ALA88 3.9 69.1 1.0 CE1 E:HIS87 4.0 77.8 1.0 C E:GLN89 4.0 61.5 1.0 CA E:GLU90 4.1 69.2 1.0 HE2 E:HIS87 4.1 92.4 1.0 O D:THR465 4.1 66.4 1.0 CB D:ASN468 4.2 58.0 1.0 HZ3 F:LYS10 4.2 0.8 1.0 H D:ALA469 4.3 77.0 1.0 H D:LEU467 4.4 73.0 1.0 C D:LEU467 4.4 61.7 1.0 NE2 E:HIS87 4.4 77.2 1.0 HA D:LEU467 4.5 70.4 1.0 OD1 D:ASN468 4.5 66.1 1.0 HG1 D:THR465 4.5 87.9 1.0 O E:GLU90 4.5 61.7 1.0 C D:ASN468 4.6 61.5 1.0 CG E:GLN89 4.6 61.9 1.0 HG3 E:GLN89 4.6 74.1 1.0 HD3 F:LYS10 4.7 0.9 1.0 N D:LEU467 4.7 61.0 1.0 CA D:LEU467 4.8 58.9 1.0 N D:ALA469 4.8 64.3 1.0 CG D:ASN468 4.8 61.5 1.0 CB E:GLN89 4.8 60.0 1.0 HA E:GLU90 4.8 82.8 1.0 C E:ALA88 4.8 62.6 1.0 C E:GLU90 4.8 68.0 1.0 N E:GLN89 4.9 63.4 1.0 HB3 D:ASN468 5.0 69.3 1.0

S.V.Antonova, M.Haffke, E.Corradini, M.Mikuciunas, T.Y.Low, L.Signor, R.M.Van Es, K.Gupta, E.Scheer, H.R.Vos, L.Tora, A.J.R.Heck, H.T.M.Timmers, I.Berger. Chaperonin Cct Checkpoint Function in Basal Transcription Factor Tfiid Assembly. Nat. Struct. Mol. Biol. V. 25 1119 2018.
ISSN: ESSN 1545-9985
PubMed: 30510221
DOI: 10.1038/S41594-018-0156-Z