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Chlorine in PDB 6fbv: Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin

Enzymatic activity of Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin

All present enzymatic activity of Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin:
2.7.7.6;

Other elements in 6fbv:

The structure of Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin (pdb code 6fbv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin, PDB code: 6fbv:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 6fbv

Go back to Chlorine Binding Sites List in 6fbv
Chlorine binding site 1 out of 2 in the Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1904

b:0.2
occ:1.00
CL1 D:FI81904 0.0 0.2 1.0
C36 D:FI81904 1.7 92.2 1.0
C37 D:FI81904 2.7 98.0 1.0
C35 D:FI81904 2.7 85.4 1.0
O12 D:FI81904 2.9 0.4 1.0
O13 D:FI81904 3.0 81.9 1.0
CG1 C:VAL1097 4.0 64.4 1.0
C38 D:FI81904 4.0 92.2 1.0
C34 D:FI81904 4.0 84.7 1.0
C39 D:FI81904 4.5 83.4 1.0
NZ D:LYS86 4.6 54.2 1.0
NH1 D:ARG84 4.9 69.5 1.0
CD D:LYS86 4.9 57.1 1.0

Chlorine binding site 2 out of 2 in 6fbv

Go back to Chlorine Binding Sites List in 6fbv
Chlorine binding site 2 out of 2 in the Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Single Particle Cryo Em Structure of Mycobacterium Tuberculosis Rna Polymerase in Complex with Fidaxomicin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1904

b:0.7
occ:1.00
CL2 D:FI81904 0.0 0.7 1.0
C38 D:FI81904 1.7 92.2 1.0
C39 D:FI81904 2.7 83.4 1.0
C37 D:FI81904 2.7 98.0 1.0
NZ C:LYS1101 2.9 64.8 1.0
O12 D:FI81904 3.0 0.4 1.0
C40 D:FI81904 3.0 82.1 1.0
CE C:LYS1101 3.7 64.9 1.0
NH2 D:ARG84 3.9 79.8 1.0
C34 D:FI81904 4.0 84.7 1.0
C36 D:FI81904 4.0 92.2 1.0
C41 D:FI81904 4.2 89.1 1.0
C35 D:FI81904 4.5 85.4 1.0
CG1 C:VAL1100 4.7 45.5 1.0
CZ D:ARG84 4.8 74.8 1.0

Reference:

W.Lin, K.Das, D.Degen, A.Mazumder, D.Duchi, D.Wang, Y.W.Ebright, R.Y.Ebright, E.Sineva, M.Gigliotti, A.Srivastava, S.Mandal, Y.Jiang, Y.Liu, R.Yin, Z.Zhang, E.T.Eng, D.Thomas, S.Donadio, H.Zhang, C.Zhang, A.N.Kapanidis, R.H.Ebright. Structural Basis of Transcription Inhibition By Fidaxomicin (Lipiarmycin A3). Mol. Cell V. 70 60 2018.
ISSN: ISSN 1097-4164
PubMed: 29606590
DOI: 10.1016/J.MOLCEL.2018.02.026
Page generated: Sat Jul 27 23:12:17 2024

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