Chlorine in PDB 6fia: Structure of the Human Line-1 ORF1P Coiled Coil Domain

The structure of Structure of the Human Line-1 ORF1P Coiled Coil Domain, PDB code: 6fia was solved by E.Khazina, O.Weichenrieder, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	125.31 / 2.65
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	92.160, 250.610, 33.830, 90.00, 90.00, 90.00
R / Rfree (%)	20.8 / 23.8

The binding sites of Chlorine atom in the Structure of the Human Line-1 ORF1P Coiled Coil Domain (pdb code 6fia). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of the Human Line-1 ORF1P Coiled Coil Domain, PDB code: 6fia:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structure of the Human Line-1 ORF1P Coiled Coil Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Human Line-1 ORF1P Coiled Coil Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:79.9 occ:1.00 NH1 B:ARG135 3.1 81.6 1.0 NH2 A:ARG135 3.2 53.8 1.0 NH2 C:ARG135 3.4 68.4 1.0 NE A:ARG135 3.5 62.9 1.0 CZ A:ARG135 3.8 65.6 1.0 NE C:ARG135 4.0 64.6 1.0 CD B:ARG135 4.1 80.0 1.0 CZ C:ARG135 4.2 75.4 1.0 CZ B:ARG135 4.2 92.3 1.0 CA C:GLY132 4.4 58.1 1.0 NE B:ARG135 4.6 84.5 1.0 CA B:GLY132 4.6 53.2 1.0 CD A:ARG135 4.8 56.1 1.0 CA A:GLY132 4.8 44.8 1.0

Chlorine binding site 2 out of 4 in the Structure of the Human Line-1 ORF1P Coiled Coil Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of the Human Line-1 ORF1P Coiled Coil Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:60.0 occ:1.00 ND2 C:ASN142 3.0 50.6 1.0 ND2 A:ASN142 3.0 41.1 1.0 ND2 B:ASN142 3.0 49.5 1.0 CB C:ASN142 3.8 54.7 1.0 CB A:ASN142 3.8 43.3 1.0 CG C:ASN142 3.8 68.2 1.0 CB B:ASN142 3.9 45.6 1.0 CG A:ASN142 3.9 50.1 1.0 CG B:ASN142 3.9 60.0 1.0 CG1 C:ILE139 4.1 52.1 1.0 CA C:ILE139 4.2 54.2 1.0 CA A:ILE139 4.3 46.0 1.0 CA B:ILE139 4.4 46.0 1.0 CG2 A:ILE139 4.4 48.3 1.0 CG1 A:ILE139 4.4 48.2 1.0 CG1 B:ILE139 4.5 48.1 1.0 CB C:ILE139 4.5 54.9 1.0 CG2 C:ILE139 4.5 55.8 1.0 CG2 B:ILE139 4.6 46.1 1.0 CB A:ILE139 4.6 48.5 1.0 CB B:ILE139 4.7 47.5 1.0 O C:ILE139 4.8 64.9 1.0 O A:ILE139 4.9 54.5 1.0 O B:ILE139 4.9 50.5 1.0

Chlorine binding site 3 out of 4 in the Structure of the Human Line-1 ORF1P Coiled Coil Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of the Human Line-1 ORF1P Coiled Coil Domain within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl501 b:63.9 occ:1.00 ND2 D:ASN142 3.0 53.5 1.0 ND2 E:ASN142 3.1 43.2 1.0 ND2 F:ASN142 3.1 58.9 1.0 CB D:ASN142 3.7 43.8 1.0 CB E:ASN142 3.8 42.1 1.0 CB F:ASN142 3.8 52.1 1.0 CG D:ASN142 3.8 62.1 1.0 CG E:ASN142 3.9 55.5 1.0 CG F:ASN142 3.9 68.9 1.0 CA E:ILE139 4.2 45.7 1.0 CA D:ILE139 4.2 45.5 1.0 CG1 E:ILE139 4.3 50.2 1.0 CA F:ILE139 4.3 46.7 1.0 CG2 E:ILE139 4.4 52.2 1.0 CB E:ILE139 4.5 49.5 1.0 CG2 F:ILE139 4.5 43.9 1.0 CG1 F:ILE139 4.5 48.4 1.0 CG1 D:ILE139 4.5 45.3 1.0 CG2 D:ILE139 4.6 47.4 1.0 CB F:ILE139 4.7 47.7 1.0 CB D:ILE139 4.7 46.9 1.0 O E:ILE139 4.7 53.7 1.0 O D:ILE139 4.8 56.0 1.0 O F:ILE139 4.8 52.5 1.0 C E:ILE139 5.0 51.8 1.0

Chlorine binding site 4 out of 4 in the Structure of the Human Line-1 ORF1P Coiled Coil Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of the Human Line-1 ORF1P Coiled Coil Domain within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl502 b:73.2 occ:1.00 NH2 F:ARG135 3.0 80.1 1.0 NH2 D:ARG135 3.2 66.9 1.0 NH1 E:ARG135 3.4 68.7 1.0 NE F:ARG135 3.6 76.7 1.0 CZ F:ARG135 3.7 88.1 1.0 NE D:ARG135 3.7 70.1 1.0 CZ D:ARG135 3.9 72.3 1.0 CA F:GLY132 4.1 48.2 1.0 CD E:ARG135 4.4 69.0 1.0 CZ E:ARG135 4.5 74.3 1.0 CA D:GLY132 4.8 52.7 1.0 CA E:GLY132 4.9 47.5 1.0 NE E:ARG135 4.9 71.0 1.0 CD F:ARG135 4.9 65.8 1.0 N F:GLY132 4.9 50.6 1.0

E.Khazina, O.Weichenrieder. Human Line-1 Retrotransposition Requires A Metastable Coiled Coil and A Positively Charged N-Terminus in L1ORF1P. Elife V. 7 2018.
ISSN: ESSN 2050-084X
PubMed: 29565245
DOI: 10.7554/ELIFE.34960