Chlorine in PDB 6fmd: Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold
Enzymatic activity of Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold
All present enzymatic activity of Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold:
1.3.5.2;
1.3.5.2;
Protein crystallography data
The structure of Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold, PDB code: 6fmd
was solved by
P.Goyal,
M.Jarva,
M.Andersson,
M.L.Lolli,
R.Friemann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 78.32 / 1.58 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 90.441, 90.441, 122.446, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 13.7 / 16 |
Other elements in 6fmd:
The structure of Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold also contains other interesting chemical elements:
| Fluorine | (F) | 4 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold
(pdb code 6fmd). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold, PDB code: 6fmd:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold, PDB code: 6fmd:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 6fmd
Go back to
Chlorine Binding Sites List in 6fmd
Chlorine binding site 1 out
of 2 in the Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 6fmd
Go back to
Chlorine Binding Sites List in 6fmd
Chlorine binding site 2 out
of 2 in the Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Targeting Myeloid Differentiation Using Potent Human Dihydroorotate Dehydrogenase (Hdhodh) Inhibitors Based on 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold within 5.0Å range:
|
Reference:
S.Sainas,
A.C.Pippione,
E.Lupino,
M.Giorgis,
P.Circosta,
V.Gaidano,
P.Goyal,
D.Bonanni,
B.Rolando,
A.Cignetti,
A.Ducime,
M.Andersson,
M.Jarva,
R.Friemann,
M.Piccinini,
C.Ramondetti,
B.Buccinna,
S.Al-Karadaghi,
D.Boschi,
G.Saglio,
M.L.Lolli.
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- A]Pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors. J. Med. Chem. V. 61 6034 2018.
ISSN: ISSN 1520-4804
PubMed: 29939742
DOI: 10.1021/ACS.JMEDCHEM.8B00373
Page generated: Sat Dec 12 12:59:10 2020
ISSN: ISSN 1520-4804
PubMed: 29939742
DOI: 10.1021/ACS.JMEDCHEM.8B00373
Last articles
Zn in 8WB0Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
