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Chlorine in PDB 6fpu: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-OneEnzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29; Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6fpu
was solved by
A.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6fpu:
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One
(pdb code 6fpu). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One, PDB code: 6fpu: Chlorine binding site 1 out of 1 in 6fpuGo back to Chlorine Binding Sites List in 6fpu
Chlorine binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3AS,5AR,8BS)-2,2,7,7-Tetramethyltetrahydro-3AH-Bis([1, 3]Dioxolo)[4,5-B:4',5'-D]Pyran-3A-Yl)Methyl)Amino)-1,7-Dihydro-8H- Imidazo[4,5-G]Quinazolin-8-One
Mono view Stereo pair view
Reference:
L.D.Movsisyan,
E.Schafer,
A.Nguyen,
F.R.Ehrmann,
A.Schwab,
T.Rossolini,
D.Zimmerli,
B.Wagner,
H.Daff,
A.Heine,
G.Klebe,
F.Diederich.
Sugar Acetonides Are A Superior Motif For Addressing the Large, Solvent-Exposed Ribose-33 Pocket of Trna-Guanine Transglycosylase. Chemistry V. 24 9957 2018.
Page generated: Sat Dec 12 12:59:37 2020
ISSN: ISSN 1521-3765 PubMed: 29939431 DOI: 10.1002/CHEM.201801756 |
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