Chlorine in PDB 6g2a: Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm

Enzymatic activity of Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm

All present enzymatic activity of Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm:
3.2.2.19;

Protein crystallography data

The structure of Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm, PDB code: 6g2a was solved by A.Ariza, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 78.09 / 1.80
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 98.526, 42.940, 89.231, 90.00, 118.93, 90.00
R / Rfree (%) 18.1 / 22

Other elements in 6g2a:

The structure of Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm (pdb code 6g2a). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm, PDB code: 6g2a:

Chlorine binding site 1 out of 1 in 6g2a

Go back to Chlorine Binding Sites List in 6g2a
Chlorine binding site 1 out of 1 in the Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human [Protein Adp-Ribosylargenine] Hydrolase ARH1 in Complex with Adp-Hpm within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl404

b:47.2
occ:1.00
O A:HOH511 2.7 28.0 1.0
N A:LEU43 2.8 31.6 1.0
NE2 A:HIS294 2.9 31.2 1.0
O A:HOH624 3.0 46.7 1.0
CA A:GLY42 3.4 33.3 1.0
C A:GLY42 3.6 31.8 1.0
CB A:LEU43 3.6 30.3 1.0
CE1 A:HIS294 3.7 32.6 1.0
CD2 A:LEU37 3.7 28.8 1.0
CA A:LEU43 3.8 30.6 1.0
CG A:LEU37 4.0 29.1 1.0
CD2 A:HIS294 4.0 29.4 1.0
OXT A:ACT405 4.1 42.4 1.0
CD1 A:LEU37 4.4 28.3 1.0
C A:ACT405 4.4 43.4 1.0
CE A:LYS290 4.5 38.6 1.0
CH3 A:ACT405 4.6 45.5 1.0
O A:GLY42 4.8 31.1 1.0
CD A:LYS290 4.8 38.3 1.0
N A:GLY42 4.8 33.6 1.0
ND1 A:HIS294 4.9 31.9 1.0
CG A:LYS290 5.0 35.7 1.0

Reference:

J.G.M.Rack, A.Ariza, B.S.Drown, C.Henfrey, E.Bartlett, T.Shirai, P.J.Hergenrother, I.Ahel. (Adp-Ribosyl)Hydrolases: Structural Basis For Differential Substrate Recognition and Inhibition. Cell Chem Biol V. 25 1533 2018.
ISSN: ESSN 2451-9448
PubMed: 30472116
DOI: 10.1016/J.CHEMBIOL.2018.11.001
Page generated: Sat Dec 12 13:00:26 2020

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