Chlorine in PDB 6g2u: Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)

All present enzymatic activity of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2):
1.4.1.3;

The structure of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2), PDB code: 6g2u was solved by V.F.Fadouloglou, C.Dimovasili, M.Providaki, D.Kotsifaki, I.Sarrou, A.Plaitakis, I.Zaganas, M.Kokkinidis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.65 / 2.93
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	121.795, 149.304, 433.315, 90.00, 90.00, 90.00
R / Rfree (%)	19.3 / 24.9

The structure of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) also contains other interesting chemical elements:

Sodium

(Na)

21 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 19;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) (pdb code 6g2u). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 19 binding sites of Chlorine where determined in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2), PDB code: 6g2u:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl607 b:59.4 occ:1.00 NH1 A:ARG247 3.5 64.3 1.0 O E:HOH839 3.9 60.3 1.0 NH2 A:ARG247 4.2 73.0 1.0 CZ A:ARG247 4.2 70.6 1.0 O E:THR431 4.8 49.6 1.0

Chlorine binding site 2 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl608 b:83.4 occ:1.00 O A:HOH966 3.3 52.5 1.0 NH1 A:ARG70 3.8 71.7 1.0 CD A:ARG70 3.9 73.4 1.0 CZ A:ARG70 4.7 79.2 1.0 NE A:ARG70 4.8 81.8 1.0 CG A:ARG70 5.0 68.5 1.0

Chlorine binding site 3 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl609 b:87.6 occ:1.00 O A:HOH925 3.1 68.3 1.0 NH2 A:ARG46 3.4 63.0 1.0 O A:GLU42 3.5 78.6 1.0 CB A:GLU42 3.6 63.6 1.0 NE A:ARG46 3.6 74.6 1.0 O A:HOH843 3.8 72.0 1.0 CG1 A:VAL33 3.9 61.9 1.0 CG A:GLU42 4.0 68.7 1.0 CZ A:ARG46 4.0 63.5 1.0 C A:GLU42 4.0 73.0 1.0 CA A:GLU42 4.3 70.7 1.0 O A:HOH871 4.5 63.4 1.0 O A:HOH988 4.6 57.3 1.0 O A:HOH951 4.8 63.5 1.0 CD A:ARG46 4.8 76.6 1.0 N A:GLU43 4.9 71.1 1.0 O A:HOH711 4.9 65.7 1.0 CB A:ARG46 5.0 72.9 1.0

Chlorine binding site 4 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl606 b:73.8 occ:1.00 O A:HOH713 3.5 31.2 1.0 ND2 B:ASN197 3.6 47.3 1.0 ND2 A:ASN197 3.8 33.8 1.0 ND2 D:ASN197 3.9 39.8 1.0 OD1 B:ASN197 4.3 44.8 1.0 CG B:ASN197 4.4 45.0 1.0 OD1 A:ASN197 4.5 43.2 1.0 CG A:ASN197 4.6 36.0 1.0 O D:HOH1006 4.7 66.0 1.0 OD1 D:ASN197 4.8 47.1 1.0 CG D:ASN197 4.8 37.8 1.0 CG2 B:ILE196 4.9 32.8 1.0 NA D:NA613 5.0 34.5 1.0

Chlorine binding site 5 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl607 b:89.8 occ:1.00 OD1 B:ASN47 3.8 69.0 1.0 CB B:ARG50 3.9 56.6 1.0 NH2 B:ARG54 4.0 59.0 1.0 CD B:ARG50 4.1 57.3 1.0 CG B:ARG50 4.2 61.2 1.0 NH1 B:ARG54 4.6 68.1 1.0 CA B:ASN47 4.8 59.3 1.0 CZ B:ARG54 4.8 68.9 1.0 CG B:ASN47 4.8 69.5 1.0 O B:ARG46 4.9 61.2 1.0

Chlorine binding site 6 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl608 b:60.3 occ:1.00 O C:HOH909 3.0 64.9 1.0 O C:HOH718 3.5 67.5 1.0 O C:HOH925 3.5 57.2 1.0 CD2 C:HIS213 3.6 48.5 1.0 O C:HOH927 3.6 73.5 1.0 N C:GLY214 3.8 47.9 1.0 CE C:LYS450 3.8 68.6 1.0 CB C:HIS213 4.1 47.5 1.0 CG C:HIS213 4.1 51.9 1.0 CA C:HIS213 4.2 41.0 1.0 O C:HOH716 4.2 55.9 1.0 O C:HOH853 4.4 58.6 1.0 NZ C:LYS450 4.4 64.6 1.0 C C:HIS213 4.5 46.0 1.0 CD C:LYS450 4.6 65.4 1.0 CA C:GLY214 4.7 51.7 1.0 CD1 C:ILE216 4.7 57.0 1.0 NE2 C:HIS213 4.7 49.9 1.0 CB C:LYS450 4.9 49.6 1.0 O C:HOH862 4.9 71.3 1.0

Chlorine binding site 7 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl609 b:74.6 occ:1.00 O F:HOH737 3.4 49.7 1.0 NH1 F:ARG423 4.4 55.2 1.0 O F:HOH738 4.8 46.1 1.0 N C:ALA438 4.9 59.8 1.0 O C:PRO436 5.0 44.9 1.0 CZ F:ARG423 5.0 59.0 1.0

Chlorine binding site 8 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl614 b:70.1 occ:1.00 O D:HIS268 3.9 49.9 1.0 O D:ARG269 4.0 52.2 1.0 C D:ARG269 4.7 43.3 1.0 CA D:ARG269 4.9 47.2 1.0 CE1 D:HIS268 4.9 56.3 1.0 NE2 D:HIS268 5.0 56.5 1.0

Chlorine binding site 9 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl615 b:74.8 occ:1.00 O D:HOH944 3.3 47.5 1.0 O D:HOH1039 3.5 53.9 1.0 O D:HOH809 3.7 59.1 1.0 O F:HOH839 3.7 49.5 1.0 O F:HOH846 3.9 56.7 1.0 OD1 D:ASN286 4.6 50.8 1.0 O D:HOH782 4.6 60.0 1.0 OD2 D:ASP288 4.9 76.3 1.0

Chlorine binding site 10 out of 19 in the Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl616 b:74.9 occ:1.00 O D:HOH954 3.2 51.6 1.0 CB D:SER64 3.7 41.3 1.0 O D:SER64 3.8 44.8 1.0 C D:SER64 4.0 41.7 1.0 O D:LEU65 4.3 41.0 1.0 N D:LEU65 4.4 41.0 1.0 C D:LEU65 4.4 35.5 1.0 CA D:SER64 4.5 38.2 1.0 CB D:SER66 4.6 33.0 1.0 CA D:LEU65 4.8 33.0 1.0 OG D:SER64 4.9 39.9 1.0 N D:SER66 4.9 39.9 1.0

V.F.Fadouloglou, C.Dimovasili, M.Providaki, D.Kotsifaki, I.Sarrou, A.Plaitakis, I.Zaganas, M.Kokkinidis. Crystal Structure of the Human Glutamate Dehydrogenase 2 (HGDH2) To Be Published.