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Chlorine in PDB 6gcw: Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible InhibitorEnzymatic activity of Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor
All present enzymatic activity of Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor:
2.7.10.2; Protein crystallography data
The structure of Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor, PDB code: 6gcw
was solved by
E.Yen-Pon,
B.Li,
M.Acebron-Garcia-De-Eulate,
C.Tomkiewicz-Raulet,
J.Dawson,
D.Lietha,
M.C.Frame,
X.Coumoul,
C.Garbay,
M.Etheve-Quelquejeu,
H.Chen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor
(pdb code 6gcw). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor, PDB code: 6gcw: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6gcwGo back to Chlorine Binding Sites List in 6gcw
Chlorine binding site 1 out
of 2 in the Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6gcwGo back to Chlorine Binding Sites List in 6gcw
Chlorine binding site 2 out
of 2 in the Focal Adhesion Kinase Catalytic Domain in Complex with Irreversible Inhibitor
Mono view Stereo pair view
Reference:
E.Yen-Pon,
B.Li,
M.Acebron-Garcia-De-Eulate,
C.Tomkiewicz-Raulet,
J.Dawson,
D.Lietha,
M.C.Frame,
X.Coumoul,
C.Garbay,
M.Etheve-Quelquejeu,
H.Chen.
Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. Acs Chem.Biol. V. 13 2067 2018.
Page generated: Sat Dec 12 13:01:35 2020
ISSN: ESSN 1554-8937 PubMed: 29897729 DOI: 10.1021/ACSCHEMBIO.8B00250 |
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