Chlorine in PDB 6gk7: Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318)

The structure of Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318), PDB code: 6gk7 was solved by S.Steinbacher, M.Mrosek, J.Juraszek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	88.20 / 2.95
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	93.829, 60.524, 91.048, 90.00, 104.37, 90.00
R / Rfree (%)	22 / 26.8

The binding sites of Chlorine atom in the Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318) (pdb code 6gk7). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318), PDB code: 6gk7:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318) within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl301 b:35.1 occ:1.00 ND1 H:HIS173 3.1 28.4 1.0 OD1 L:ASP173 3.3 27.7 1.0 CE1 H:HIS173 3.5 29.6 1.0 OE2 L:GLU171 3.9 33.1 1.0 CB L:THR170 4.3 25.7 1.0 CG2 L:THR170 4.3 25.6 1.0 O L:GLU171 4.3 26.0 1.0 O H:VAL172 4.3 25.8 1.0 CG H:HIS173 4.4 27.6 1.0 CD L:GLU171 4.4 31.7 1.0 CG L:ASP173 4.5 26.7 1.0 OG1 L:THR170 4.6 24.2 1.0 OE1 L:GLU171 4.8 31.4 1.0 NE2 H:HIS173 4.8 29.4 1.0 CA H:HIS173 4.8 25.4 1.0 CB L:ASP173 4.9 25.6 1.0 CA L:ASP173 4.9 26.2 1.0 CB H:HIS173 5.0 26.6 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Anti-Tau Antibody Dmcbtau-27.1, Double Mutant (S31Y, T100I) of Cbtau-27.1, in Complex with Tau Peptide A8119B (Residues 299-318) within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl302 b:37.3 occ:1.00 O H:HOH404 3.4 15.5 1.0 OE1 H:GLN201 3.5 25.9 1.0 O H:THR202 3.8 27.8 1.0 ND2 H:ASN164 4.1 28.0 1.0 N H:THR202 4.2 27.5 1.0 CD H:GLN201 4.5 26.4 1.0 OG1 H:THR202 4.5 32.1 1.0 CB H:GLN201 4.6 26.1 1.0 CA H:GLN201 4.6 27.6 1.0 C H:THR202 4.7 27.9 1.0 CG H:ASN164 4.8 28.6 1.0 C H:GLN201 4.9 27.1 1.0 CA H:THR202 5.0 28.9 1.0

A.Apetri, R.Crespo, J.Juraszek, G.Pascual, R.Janson, X.Zhu, H.Zhang, E.Keogh, T.Holland, J.Wadia, H.Verveen, B.Siregar, M.Mrosek, R.Taggenbrock, J.Ameijde, H.Inganas, M.Van Winsen, M.H.Koldijk, D.Zuijdgeest, M.Borgers, K.Dockx, E.J.M.Stoop, W.Yu, E.C.Brinkman-Van Der Linden, K.Ummenthum, K.Van Kolen, M.Mercken, S.Steinbacher, D.De Marco, J.J.Hoozemans, I.A.Wilson, W.Koudstaal, J.Goudsmit. A Common Antigenic Motif Recognized By Naturally Occurring Human VH5-51/VL4-1 Anti-Tau Antibodies with Distinct Functionalities. Acta Neuropathol Commun V. 6 43 2018.
ISSN: ISSN 2051-5960
PubMed: 29855358
DOI: 10.1186/S40478-018-0543-Z