Chlorine in PDB 6gk8: Crystal Structure of Anti-Tau Antibody Dmcbtau-28.1, Double Mutant (S32R, E35K) of Cbtau-28.1, in Complex with Tau Peptide A7731 (Residues 52-71)

The structure of Crystal Structure of Anti-Tau Antibody Dmcbtau-28.1, Double Mutant (S32R, E35K) of Cbtau-28.1, in Complex with Tau Peptide A7731 (Residues 52-71), PDB code: 6gk8 was solved by S.Steinbacher, M.Mrosek, J.Juraszek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	70.95 / 2.85
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.313, 63.601, 141.895, 90.00, 90.00, 90.00
R / Rfree (%)	23.6 / 27.8

The binding sites of Chlorine atom in the Crystal Structure of Anti-Tau Antibody Dmcbtau-28.1, Double Mutant (S32R, E35K) of Cbtau-28.1, in Complex with Tau Peptide A7731 (Residues 52-71) (pdb code 6gk8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Anti-Tau Antibody Dmcbtau-28.1, Double Mutant (S32R, E35K) of Cbtau-28.1, in Complex with Tau Peptide A7731 (Residues 52-71), PDB code: 6gk8:

Chlorine binding site 1 out of 1 in the Crystal Structure of Anti-Tau Antibody Dmcbtau-28.1, Double Mutant (S32R, E35K) of Cbtau-28.1, in Complex with Tau Peptide A7731 (Residues 52-71)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Anti-Tau Antibody Dmcbtau-28.1, Double Mutant (S32R, E35K) of Cbtau-28.1, in Complex with Tau Peptide A7731 (Residues 52-71) within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl301 b:40.7 occ:1.00 N H:TRP47 3.2 36.5 1.0 N L:PHE104 3.4 34.6 1.0 CA L:THR103 3.7 35.7 1.0 CA H:GLU46 3.8 37.4 1.0 CB L:THR103 3.8 35.2 1.0 CB H:TRP47 3.9 38.5 1.0 CG2 L:THR103 4.0 35.0 1.0 C H:GLU46 4.0 35.4 1.0 CA H:TRP47 4.1 37.1 1.0 C L:THR103 4.1 35.1 1.0 CD1 L:PHE104 4.2 34.1 1.0 O H:LEU45 4.2 33.6 1.0 O L:PHE104 4.2 41.8 1.0 CA L:PHE104 4.4 35.5 1.0 CB L:PHE104 4.5 35.3 1.0 O H:TRP47 4.6 38.6 1.0 CB H:GLU46 4.7 40.4 1.0 C L:PHE104 4.8 37.1 1.0 N H:GLU46 4.8 37.6 1.0 C H:TRP47 4.8 36.6 1.0 CG L:PHE104 4.9 33.9 1.0 C H:LEU45 4.9 36.4 1.0 N L:THR103 5.0 35.6 1.0

A.Apetri, R.Crespo, J.Juraszek, G.Pascual, R.Janson, X.Zhu, H.Zhang, E.Keogh, T.Holland, J.Wadia, H.Verveen, B.Siregar, M.Mrosek, R.Taggenbrock, J.Ameijde, H.Inganas, M.Van Winsen, M.H.Koldijk, D.Zuijdgeest, M.Borgers, K.Dockx, E.J.M.Stoop, W.Yu, E.C.Brinkman-Van Der Linden, K.Ummenthum, K.Van Kolen, M.Mercken, S.Steinbacher, D.De Marco, J.J.Hoozemans, I.A.Wilson, W.Koudstaal, J.Goudsmit. A Common Antigenic Motif Recognized By Naturally Occurring Human VH5-51/VL4-1 Anti-Tau Antibodies with Distinct Functionalities. Acta Neuropathol Commun V. 6 43 2018.
ISSN: ISSN 2051-5960
PubMed: 29855358
DOI: 10.1186/S40478-018-0543-Z