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Chlorine in PDB 6gqm: Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229Enzymatic activity of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
All present enzymatic activity of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229, PDB code: 6gqm
was solved by
M.Schimpl,
C.J.Hardy,
D.J.Ogg,
R.C.Overman,
M.J.Packer,
J.G.Kettle,
R.Anjum,
E.Barry,
D.Bhavsar,
C.Brown,
A.Campbell,
K.Goldberg,
M.Grondine,
S.Guichard,
T.Hunt,
O.Jones,
X.Li,
O.Moleva,
S.Pearson,
W.Shao,
A.Smith,
J.Smith,
D.Stead,
S.Stokes,
M.Tucker,
Y.Ye,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6gqm:
The structure of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
(pdb code 6gqm). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229, PDB code: 6gqm: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6gqmGo back to Chlorine Binding Sites List in 6gqm
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6gqmGo back to Chlorine Binding Sites List in 6gqm
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
Mono view Stereo pair view
Reference:
J.G.Kettle,
R.Anjum,
E.Barry,
D.Bhavsar,
C.Brown,
S.Boyd,
A.Campbell,
K.Goldberg,
M.Grondine,
S.Guichard,
C.J.Hardy,
T.Hunt,
R.D.O.Jones,
X.Li,
O.Moleva,
D.Ogg,
R.C.Overman,
M.J.Packer,
S.Pearson,
M.Schimpl,
W.Shao,
A.Smith,
J.M.Smith,
D.Stead,
S.Stokes,
M.Tucker,
Y.Ye.
Discovery of N-(4-{[5-Fluoro-7-(2-Methoxyethoxy) Quinazolin-4-Yl]Amino}Phenyl)-2-[4-(Propan-2-Yl)-1 H-1,2,3-Triazol-1-Yl]Acetamide (AZD3229), A Potent Pan-Kit Mutant Inhibitor For the Treatment of Gastrointestinal Stromal Tumors. J. Med. Chem. V. 61 8797 2018.
Page generated: Sat Dec 12 13:02:28 2020
ISSN: ISSN 1520-4804 PubMed: 30204441 DOI: 10.1021/ACS.JMEDCHEM.8B00938 |
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