Chlorine in PDB 6gva: CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455
Enzymatic activity of CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455
All present enzymatic activity of CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455:
2.7.11.22;
2.7.11.22;
Protein crystallography data
The structure of CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455, PDB code: 6gva
was solved by
J.Skerlova,
P.Rezacova,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 48.00 / 2.15 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 71.015, 112.642, 159.690, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.4 / 24 |
Other elements in 6gva:
The structure of CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455 also contains other interesting chemical elements:
| Bromine | (Br) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455
(pdb code 6gva). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455, PDB code: 6gva:
In total only one binding site of Chlorine was determined in the CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455, PDB code: 6gva:
Chlorine binding site 1 out of 1 in 6gva
Go back to
Chlorine Binding Sites List in 6gva
Chlorine binding site 1 out
of 1 in the CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of CDK2/Cyclin A2 in Complex with Pyrazolo[4,3-D]Pyrimidine Inhibitor LGR4455 within 5.0Å range:
|
Reference:
R.Jorda,
L.Havlicek,
A.Sturc,
D.Tuskova,
L.Daumova,
M.Alam,
J.Skerlova,
M.Nekardova,
M.Perina,
T.Pospisil,
J.Siroka,
L.Urbanek,
P.Pachl,
P.Rezacova,
M.Strnad,
P.Klener,
V.Krystof.
3,5,7-Substituted Pyrazolo[4,3- D]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models. J.Med.Chem. V. 62 4606 2019.
ISSN: ISSN 0022-2623
PubMed: 30943029
DOI: 10.1021/ACS.JMEDCHEM.9B00189
Page generated: Sat Dec 12 13:02:53 2020
ISSN: ISSN 0022-2623
PubMed: 30943029
DOI: 10.1021/ACS.JMEDCHEM.9B00189
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