Chlorine in PDB 6h42: Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Enzymatic activity of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
All present enzymatic activity of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1:
2.4.2.29;
Protein crystallography data
The structure of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1, PDB code: 6h42
was solved by
S.Johannsson,
P.Neumann,
R.Ficner,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
48.25 /
2.45
|
Space group
|
C 1 2 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
127.700,
157.820,
47.770,
90.00,
108.46,
90.00
|
R / Rfree (%)
|
20.2 /
23.1
|
Other elements in 6h42:
The structure of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
(pdb code 6h42). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 10 binding sites of Chlorine where determined in the
Crystal Structure of the Human Tgt Catalytic Subunit QTRT1, PDB code: 6h42:
Jump to Chlorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Chlorine binding site 1 out
of 10 in 6h42
Go back to
Chlorine Binding Sites List in 6h42
Chlorine binding site 1 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl503
b:77.4
occ:1.00
|
SG
|
A:CYS23
|
3.3
|
67.8
|
1.0
|
CA
|
A:LYS367
|
3.5
|
53.6
|
1.0
|
CA
|
A:CYS23
|
3.6
|
62.7
|
1.0
|
CB
|
A:CYS23
|
3.7
|
66.3
|
1.0
|
C
|
A:LYS367
|
3.7
|
53.9
|
1.0
|
N
|
A:SER24
|
4.0
|
62.7
|
1.0
|
N
|
A:PHE369
|
4.0
|
47.4
|
1.0
|
CD
|
A:PRO370
|
4.1
|
47.4
|
1.0
|
N
|
A:ARG368
|
4.1
|
51.4
|
1.0
|
O
|
A:LYS367
|
4.2
|
57.6
|
1.0
|
CB
|
A:PHE369
|
4.2
|
44.6
|
1.0
|
CB
|
A:LYS367
|
4.3
|
54.4
|
1.0
|
C
|
A:CYS23
|
4.3
|
63.9
|
1.0
|
O
|
A:ILE364
|
4.5
|
57.6
|
1.0
|
N
|
A:LYS367
|
4.5
|
54.6
|
1.0
|
OG
|
A:SER24
|
4.6
|
65.1
|
1.0
|
N
|
A:CYS23
|
4.7
|
60.2
|
1.0
|
CA
|
A:PHE369
|
4.7
|
47.1
|
1.0
|
CA
|
A:ARG368
|
4.8
|
49.6
|
0.6
|
CG
|
A:LYS367
|
4.9
|
56.3
|
1.0
|
CA
|
A:ARG368
|
4.9
|
49.6
|
0.4
|
O
|
A:SER363
|
4.9
|
53.8
|
1.0
|
C
|
A:ARG368
|
5.0
|
47.5
|
1.0
|
CA
|
A:ILE364
|
5.0
|
51.0
|
1.0
|
CG
|
A:PRO370
|
5.0
|
48.8
|
1.0
|
|
Chlorine binding site 2 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 2 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl504
b:70.4
occ:1.00
|
CG2
|
A:ILE186
|
4.1
|
58.9
|
1.0
|
CD2
|
A:HIS189
|
4.3
|
69.0
|
1.0
|
CG1
|
A:VAL222
|
4.3
|
53.4
|
1.0
|
CG1
|
A:ILE186
|
4.4
|
58.0
|
1.0
|
CD
|
A:PRO223
|
4.4
|
50.9
|
1.0
|
CB
|
A:LEU197
|
4.5
|
56.4
|
1.0
|
CA
|
A:VAL222
|
4.5
|
58.2
|
1.0
|
CD2
|
A:LEU197
|
4.5
|
59.4
|
1.0
|
O
|
A:ASP221
|
4.5
|
73.0
|
1.0
|
CB
|
A:ILE186
|
4.7
|
58.7
|
1.0
|
CB
|
A:VAL222
|
4.8
|
53.8
|
1.0
|
CA
|
A:ILE186
|
4.9
|
59.0
|
1.0
|
|
Chlorine binding site 3 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 3 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl505
b:69.8
occ:1.00
|
O
|
A:HOH620
|
2.8
|
45.0
|
1.0
|
CG2
|
A:VAL305
|
3.2
|
71.7
|
1.0
|
NH2
|
B:ARG327
|
3.8
|
53.4
|
1.0
|
NH1
|
B:ARG327
|
3.9
|
56.4
|
1.0
|
CD2
|
B:LEU299
|
4.2
|
62.8
|
1.0
|
N
|
A:VAL305
|
4.3
|
71.3
|
1.0
|
CZ
|
B:ARG327
|
4.3
|
54.1
|
1.0
|
N
|
A:LYS304
|
4.5
|
75.5
|
1.0
|
CB
|
A:VAL305
|
4.6
|
71.1
|
1.0
|
C
|
A:LYS304
|
4.8
|
73.0
|
1.0
|
CA
|
A:VAL305
|
4.9
|
69.4
|
1.0
|
CB
|
A:LYS303
|
4.9
|
73.2
|
1.0
|
CB
|
A:LYS304
|
4.9
|
78.1
|
1.0
|
CA
|
A:LYS304
|
4.9
|
75.2
|
1.0
|
O
|
B:HOH648
|
5.0
|
68.5
|
1.0
|
|
Chlorine binding site 4 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 4 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl506
b:45.9
occ:0.50
|
OG
|
A:SER326
|
3.1
|
55.9
|
1.0
|
CD1
|
A:PHE310
|
3.6
|
54.4
|
1.0
|
CE1
|
A:PHE310
|
4.0
|
54.2
|
1.0
|
CB
|
A:SER326
|
4.0
|
53.8
|
1.0
|
CB
|
A:PHE329
|
4.6
|
47.9
|
1.0
|
CG
|
A:PHE310
|
4.8
|
56.6
|
1.0
|
N
|
A:SER326
|
5.0
|
51.7
|
1.0
|
|
Chlorine binding site 5 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 5 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Cl507
b:53.6
occ:1.00
|
O
|
A:CYS280
|
3.4
|
52.9
|
1.0
|
N
|
A:VAL48
|
3.8
|
45.4
|
1.0
|
CA
|
A:PRO47
|
3.8
|
44.2
|
1.0
|
CB
|
A:PRO47
|
4.0
|
43.3
|
1.0
|
OG1
|
A:THR284
|
4.0
|
69.8
|
1.0
|
CE2
|
A:PHE45
|
4.2
|
44.5
|
1.0
|
CD1
|
A:ILE350
|
4.2
|
49.5
|
1.0
|
CD
|
A:PRO283
|
4.3
|
61.9
|
1.0
|
CZ
|
A:PHE45
|
4.3
|
46.1
|
1.0
|
CA
|
A:VAL281
|
4.3
|
54.7
|
1.0
|
C
|
A:PRO47
|
4.3
|
45.3
|
1.0
|
CG1
|
A:ILE350
|
4.4
|
48.0
|
1.0
|
CG
|
A:PRO283
|
4.4
|
63.2
|
1.0
|
C
|
A:CYS280
|
4.4
|
52.2
|
1.0
|
CG2
|
A:VAL48
|
4.6
|
43.2
|
1.0
|
CB
|
A:PRO283
|
4.6
|
62.6
|
1.0
|
CB
|
A:VAL48
|
4.8
|
49.0
|
1.0
|
N
|
A:VAL281
|
4.8
|
53.2
|
1.0
|
CA
|
A:VAL48
|
4.9
|
49.9
|
1.0
|
C
|
A:VAL281
|
4.9
|
56.3
|
1.0
|
N
|
A:THR284
|
4.9
|
65.4
|
1.0
|
N
|
A:PRO47
|
5.0
|
43.2
|
1.0
|
|
Chlorine binding site 6 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 6 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl503
b:60.1
occ:1.00
|
O
|
B:HOH627
|
3.5
|
56.9
|
1.0
|
NH1
|
A:ARG327
|
3.5
|
53.9
|
1.0
|
N
|
B:VAL305
|
3.7
|
69.5
|
1.0
|
CB
|
B:VAL305
|
3.8
|
71.3
|
1.0
|
NH2
|
A:ARG327
|
3.8
|
54.5
|
1.0
|
CZ
|
A:ARG327
|
4.1
|
53.7
|
1.0
|
CD2
|
A:LEU299
|
4.2
|
65.4
|
1.0
|
N
|
B:LYS304
|
4.2
|
73.7
|
1.0
|
CA
|
B:VAL305
|
4.3
|
70.5
|
1.0
|
CB
|
B:LYS303
|
4.4
|
73.5
|
1.0
|
CG1
|
B:VAL305
|
4.5
|
71.4
|
1.0
|
C
|
B:LYS304
|
4.5
|
70.7
|
1.0
|
CA
|
B:LYS304
|
4.7
|
73.5
|
1.0
|
CB
|
B:LYS304
|
4.7
|
76.0
|
1.0
|
CG2
|
B:VAL305
|
4.7
|
72.7
|
1.0
|
C
|
B:LYS303
|
4.8
|
73.3
|
1.0
|
CG
|
B:LYS303
|
4.9
|
73.5
|
1.0
|
CD
|
B:LYS303
|
5.0
|
73.3
|
1.0
|
|
Chlorine binding site 7 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 7 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl504
b:75.0
occ:1.00
|
SG
|
B:CYS23
|
3.4
|
67.7
|
1.0
|
N
|
B:PHE369
|
3.5
|
56.9
|
1.0
|
CA
|
B:LYS367
|
3.6
|
63.7
|
1.0
|
C
|
B:LYS367
|
3.6
|
63.9
|
1.0
|
N
|
B:ARG368
|
3.7
|
62.0
|
1.0
|
CB
|
B:PHE369
|
3.7
|
53.7
|
1.0
|
CB
|
B:CYS23
|
3.8
|
65.7
|
1.0
|
CA
|
B:CYS23
|
3.8
|
65.7
|
1.0
|
CD
|
B:PRO370
|
3.9
|
55.0
|
1.0
|
CA
|
B:PHE369
|
4.2
|
55.8
|
1.0
|
O
|
B:ILE364
|
4.3
|
54.1
|
1.0
|
O
|
B:LYS367
|
4.3
|
63.8
|
1.0
|
C
|
B:ARG368
|
4.4
|
57.8
|
1.0
|
CA
|
B:ARG368
|
4.4
|
60.6
|
1.0
|
N
|
B:LYS367
|
4.5
|
62.4
|
1.0
|
O
|
B:SER363
|
4.5
|
56.1
|
1.0
|
N
|
B:SER24
|
4.5
|
67.4
|
1.0
|
CA
|
B:ILE364
|
4.5
|
51.2
|
1.0
|
CB
|
B:LYS367
|
4.5
|
65.3
|
1.0
|
C
|
B:CYS23
|
4.7
|
65.9
|
1.0
|
N
|
B:CYS23
|
4.8
|
65.3
|
1.0
|
C
|
B:ILE364
|
4.9
|
52.8
|
1.0
|
N
|
B:PRO370
|
4.9
|
54.7
|
1.0
|
CG
|
B:PHE369
|
5.0
|
50.5
|
1.0
|
|
Chlorine binding site 8 out
of 10 in 6h42
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Chlorine Binding Sites List in 6h42
Chlorine binding site 8 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl505
b:68.7
occ:1.00
|
CG2
|
B:ILE186
|
4.0
|
65.0
|
1.0
|
CD
|
B:PRO223
|
4.2
|
65.1
|
1.0
|
CD2
|
B:HIS189
|
4.3
|
66.4
|
1.0
|
CB
|
B:LEU197
|
4.4
|
54.6
|
1.0
|
CG1
|
B:VAL222
|
4.4
|
68.4
|
1.0
|
CA
|
B:VAL222
|
4.5
|
73.6
|
1.0
|
CD2
|
B:LEU197
|
4.6
|
52.2
|
1.0
|
O
|
B:ASP221
|
4.7
|
83.0
|
1.0
|
CB
|
B:ILE186
|
4.8
|
64.7
|
1.0
|
CG1
|
B:ILE186
|
4.8
|
65.3
|
1.0
|
CA
|
B:ILE186
|
4.9
|
63.6
|
1.0
|
CB
|
B:VAL222
|
4.9
|
69.6
|
1.0
|
|
Chlorine binding site 9 out
of 10 in 6h42
Go back to
Chlorine Binding Sites List in 6h42
Chlorine binding site 9 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 9 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl506
b:54.0
occ:1.00
|
O
|
B:CYS280
|
3.3
|
57.7
|
1.0
|
CA
|
B:PRO47
|
3.8
|
46.8
|
1.0
|
N
|
B:VAL48
|
3.8
|
48.4
|
1.0
|
CB
|
B:PRO47
|
4.0
|
46.8
|
1.0
|
CD
|
B:PRO283
|
4.2
|
69.7
|
1.0
|
CE2
|
B:PHE45
|
4.2
|
46.7
|
1.0
|
OG1
|
B:THR284
|
4.2
|
72.0
|
1.0
|
CG
|
B:PRO283
|
4.2
|
70.0
|
1.0
|
CD1
|
B:ILE350
|
4.3
|
55.8
|
1.0
|
CZ
|
B:PHE45
|
4.3
|
46.4
|
1.0
|
C
|
B:PRO47
|
4.3
|
47.7
|
1.0
|
CG2
|
B:VAL48
|
4.3
|
59.8
|
1.0
|
C
|
B:CYS280
|
4.4
|
55.2
|
1.0
|
CG1
|
B:ILE350
|
4.4
|
54.4
|
1.0
|
CA
|
B:VAL281
|
4.5
|
58.3
|
1.0
|
CB
|
B:PRO283
|
4.5
|
68.8
|
1.0
|
CG1
|
B:VAL48
|
4.6
|
53.5
|
1.0
|
CB
|
B:VAL48
|
4.8
|
56.5
|
1.0
|
CA
|
B:VAL48
|
4.9
|
53.0
|
1.0
|
N
|
B:THR284
|
4.9
|
71.3
|
1.0
|
N
|
B:VAL281
|
4.9
|
56.4
|
1.0
|
N
|
B:PRO47
|
5.0
|
45.9
|
1.0
|
|
Chlorine binding site 10 out
of 10 in 6h42
Go back to
Chlorine Binding Sites List in 6h42
Chlorine binding site 10 out
of 10 in the Crystal Structure of the Human Tgt Catalytic Subunit QTRT1
Mono view
Stereo pair view
|
A full contact list of Chlorine with other atoms in the Cl binding
site number 10 of Crystal Structure of the Human Tgt Catalytic Subunit QTRT1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Cl507
b:51.4
occ:0.50
|
OG
|
B:SER326
|
3.1
|
65.2
|
1.0
|
CD1
|
B:PHE310
|
3.5
|
57.9
|
1.0
|
CE1
|
B:PHE310
|
3.8
|
58.0
|
1.0
|
CB
|
B:SER326
|
4.1
|
63.7
|
1.0
|
CB
|
B:PHE329
|
4.6
|
61.5
|
1.0
|
CG
|
B:PHE310
|
4.7
|
58.4
|
1.0
|
N
|
B:PHE329
|
5.0
|
60.4
|
1.0
|
|
Reference:
S.Johannsson,
P.Neumann,
R.Ficner.
Crystal Structure of the Human Trna Guanine Transglycosylase Catalytic Subunit QTRT1. Biomolecules V. 8 2018.
ISSN: ISSN 2218-273X
PubMed: 30149595
DOI: 10.3390/BIOM8030081
Page generated: Sun Jul 28 00:28:02 2024
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