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Chlorine in PDB 6h4j: USP25 Catalytic Domain

Enzymatic activity of USP25 Catalytic Domain

All present enzymatic activity of USP25 Catalytic Domain:
3.4.19.12;

Protein crystallography data

The structure of USP25 Catalytic Domain, PDB code: 6h4j was solved by T.A.Klemm, F.Sauer, C.Kisker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.54 / 3.07
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 81.945, 202.629, 169.594, 90.00, 90.00, 90.00
R / Rfree (%) 18.1 / 23

Chlorine Binding Sites:

The binding sites of Chlorine atom in the USP25 Catalytic Domain (pdb code 6h4j). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the USP25 Catalytic Domain, PDB code: 6h4j:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 6h4j

Go back to Chlorine Binding Sites List in 6h4j
Chlorine binding site 1 out of 3 in the USP25 Catalytic Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of USP25 Catalytic Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl801

b:0.6
occ:1.00
NH2 A:ARG194 3.3 0.4 1.0
NH1 A:ARG194 4.0 0.1 1.0
CZ A:ARG194 4.1 0.4 1.0
OD1 A:ASN189 4.3 0.8 1.0
CE2 A:PHE188 5.0 97.5 1.0

Chlorine binding site 2 out of 3 in 6h4j

Go back to Chlorine Binding Sites List in 6h4j
Chlorine binding site 2 out of 3 in the USP25 Catalytic Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of USP25 Catalytic Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl802

b:0.9
occ:1.00
CH2 A:TRP609 4.5 66.4 1.0
CZ3 A:TRP609 4.6 66.0 1.0
NZ A:LYS622 4.7 0.6 1.0
CZ2 A:TRP609 4.7 66.6 1.0
ND2 A:ASN624 4.9 85.0 1.0

Chlorine binding site 3 out of 3 in 6h4j

Go back to Chlorine Binding Sites List in 6h4j
Chlorine binding site 3 out of 3 in the USP25 Catalytic Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of USP25 Catalytic Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl801

b:0.6
occ:1.00
CE2 B:TYR425 3.9 97.9 1.0
CZ B:TYR425 4.2 0.9 1.0
CD2 B:TYR425 4.2 95.1 1.0
OH B:TYR425 4.5 0.2 1.0
CE1 B:TYR425 4.7 99.5 1.0
CG B:TYR425 4.8 93.0 1.0

Reference:

F.Sauer, T.Klemm, R.B.Kollampally, I.Tessmer, R.K.Nair, N.Popov, C.Kisker. Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities. Mol.Cell V. 74 421 2019.
ISSN: ISSN 1097-2765
PubMed: 30926243
DOI: 10.1016/J.MOLCEL.2019.02.029
Page generated: Sat Jul 12 14:58:03 2025

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