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Chlorine in PDB 6hb5: Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine

Enzymatic activity of Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine

All present enzymatic activity of Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine:
6.1.1.1;

Protein crystallography data

The structure of Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine, PDB code: 6hb5 was solved by S.De Graef, L.Pang, S.V.Strelkov, S.D.Weeks, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.53 / 1.88
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 81.611, 65.049, 90.686, 90.00, 101.35, 90.00
R / Rfree (%) 19.3 / 22.4

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine (pdb code 6hb5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine, PDB code: 6hb5:

Chlorine binding site 1 out of 1 in 6hb5

Go back to Chlorine Binding Sites List in 6hb5
Chlorine binding site 1 out of 1 in the Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of E. Coli Tyrrs in Complex with 5'-O-(N-L-Tyrosyl) Sulfamoyl-Cytidine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl505

b:46.9
occ:1.00
 O A:PHE398 2.6 25.4 1.0
O A:HOH676 2.8 28.9 1.0
NH2 A:ARG403 3.0 29.7 1.0
N A:PHE398 3.5 21.7 1.0
O A:HOH684 3.6 44.4 1.0
C A:PHE398 3.6 26.3 1.0
CA A:PHE398 3.9 20.9 1.0
CZ A:ARG403 3.9 42.5 1.0
CB A:PHE397 4.0 24.6 1.0
CB A:PHE398 4.0 21.6 1.0
NH1 A:ARG403 4.0 23.0 1.0
CA A:GLY356 4.0 25.5 1.0
C A:PHE397 4.1 25.8 1.0
N A:GLY356 4.2 26.3 1.0
O A:HOH936 4.4 58.5 1.0
CD1 A:PHE397 4.4 26.1 1.0
O A:ALA357 4.4 26.1 1.0
CA A:PHE397 4.5 23.2 1.0
C A:GLY356 4.5 27.7 1.0
CG A:PHE397 4.6 25.1 1.0
OE2 A:GLU400 4.8 43.5 1.0
O A:PHE397 4.8 24.8 1.0
O A:GLY356 4.8 27.7 1.0
N A:LYS399 4.8 24.6 1.0
CD2 A:PHE398 4.9 21.2 1.0
CG A:PHE398 5.0 21.1 1.0

Reference:

M.Nautiyal, S.De Graef, L.Pang, B.Gadakh, S.V.Strelkov, S.D.Weeks, A.Van Aerschot. Comparative Analysis of Pyrimidine Substituted Aminoacyl-Sulfamoyl Nucleosides As Potential Inhibitors Targeting Class I Aminoacyl-Trna Synthetases. Eur.J.Med.Chem. V. 173 154 2019.
ISSN: ISSN 0223-5234
PubMed: 30995568
DOI: 10.1016/J.EJMECH.2019.04.003
Page generated: Sun Jul 28 00:44:58 2024

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