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Chlorine in PDB 6hd6: ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571)Enzymatic activity of ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571)
All present enzymatic activity of ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571):
2.7.10.2; Protein crystallography data
The structure of ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571), PDB code: 6hd6
was solved by
S.W.Cowan-Jacob,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6hd6:
The structure of ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571) also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571)
(pdb code 6hd6). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571), PDB code: 6hd6: Chlorine binding site 1 out of 1 in 6hd6Go back to Chlorine Binding Sites List in 6hd6
Chlorine binding site 1 out
of 1 in the ABL1 in Complex with COMPOUND6 and Imatinib (Sti-571)
Mono view Stereo pair view
Reference:
J.Schoepfer,
W.Jahnke,
G.Berellini,
S.Buonamici,
S.Cotesta,
S.W.Cowan-Jacob,
S.Dodd,
P.Drueckes,
D.Fabbro,
T.Gabriel,
J.M.Groell,
R.M.Grotzfeld,
A.Q.Hassan,
C.Henry,
V.Iyer,
D.Jones,
F.Lombardo,
A.Loo,
P.W.Manley,
X.Pelle,
G.Rummel,
B.Salem,
M.Warmuth,
A.A.Wylie,
T.Zoller,
A.L.Marzinzik,
P.Furet.
Discovery of Asciminib (ABL001), An Allosteric Inhibitor of the Tyrosine Kinase Activity of Bcr-ABL1. J. Med. Chem. V. 61 8120 2018.
Page generated: Sat Dec 12 13:04:50 2020
ISSN: ISSN 1520-4804 PubMed: 30137981 DOI: 10.1021/ACS.JMEDCHEM.8B01040 |
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