Chlorine in PDB 6hhz: Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine

Enzymatic activity of Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine

All present enzymatic activity of Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine:
6.1.1.11;

Protein crystallography data

The structure of Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine, PDB code: 6hhz was solved by L.Pang, S.De Graef, S.D.Weeks, S.V.Strelkov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.00 / 2.15
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 83.351, 83.351, 229.329, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 22.6

Other elements in 6hhz:

The structure of Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine also contains other interesting chemical elements:

Calcium (Ca) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine (pdb code 6hhz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine, PDB code: 6hhz:

Chlorine binding site 1 out of 1 in 6hhz

Go back to Chlorine Binding Sites List in 6hhz
Chlorine binding site 1 out of 1 in the Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Klebsiella Pneumoniae Seryl-Trna Synthetase in Complex with 5'-O-(N- (L-Seryl)-Sulfamoyl)Cytidine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl508

b:95.3
occ:1.00
 NH2 A:ARG8 3.5 75.8 1.0
NH1 A:ARG8 3.7 72.4 1.0
CZ A:ARG8 4.0 86.3 1.0
CB A:PRO4 4.1 54.1 1.0
C24 A:1PE509 4.3 84.1 1.0
CG A:PRO4 4.4 57.7 1.0
C14 A:1PE509 4.7 85.0 1.0

Reference:

L.Pang, M.Nautiyal, S.De Graef, S.V.Strelkov, A.Van Aerschot, S.D.Weeks. Structural Insights Into the Binding of Natural Pyrimidine Based Inhibitors of Class II Aminoacyl-Trna Synthetase To Be Published.
Page generated: Sat Dec 12 13:05:00 2020

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