Atomistry » Chlorine » PDB 6hkj-6hs1 » 6hld
Atomistry »
  Chlorine »
    PDB 6hkj-6hs1 »
      6hld »

Chlorine in PDB 6hld: X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba

Enzymatic activity of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba

All present enzymatic activity of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba:
3.4.21.75;

Protein crystallography data

The structure of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba, PDB code: 6hld was solved by S.O.Dahms, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.56 / 2.10
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 133.395, 133.395, 157.375, 90.00, 90.00, 120.00
R / Rfree (%) 17 / 19.6

Other elements in 6hld:

The structure of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba also contains other interesting chemical elements:

Calcium (Ca) 3 atoms
Sodium (Na) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba (pdb code 6hld). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba, PDB code: 6hld:

Chlorine binding site 1 out of 1 in 6hld

Go back to Chlorine Binding Sites List in 6hld
Chlorine binding site 1 out of 1 in the X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of Furin in Complex with the Cyclic Peptide C[Succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl607

b:30.1
occ:1.00
 NZ A:LYS449 3.1 26.6 1.0
OH A:TYR571 3.4 31.5 1.0
O A:HOH766 3.5 37.9 1.0
CD A:LYS449 3.9 29.8 1.0
CE A:LYS449 3.9 29.0 1.0
CE1 A:TYR571 3.9 27.7 1.0
OH A:TYR313 3.9 37.5 1.0
CE2 A:PHE275 4.0 47.9 1.0
CZ A:TYR571 4.1 29.1 1.0
O A:HOH941 4.2 26.0 1.0
CZ A:PHE275 4.6 33.6 1.0

Reference:

T.Van Lam Van, T.Ivanova, K.Hardes, M.R.Heindl, R.E.Morty, E.Bottcher-Friebertshauser, I.Lindberg, M.E.Than, S.O.Dahms, T.Steinmetzer. Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem V. 14 673 2019.
ISSN: ESSN 1860-7187
PubMed: 30680958
DOI: 10.1002/CMDC.201800807
Page generated: Sun Jul 28 00:57:06 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy