Chlorine in PDB 6hy9: The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M

The structure of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M, PDB code: 6hy9 was solved by H.D.Hu, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.95
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	181.990, 134.360, 159.180, 90.00, 101.47, 90.00
R / Rfree (%)	20.3 / 22.7

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M (pdb code 6hy9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M, PDB code: 6hy9:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:73.0 occ:1.00 N A:PHE78 3.4 66.6 1.0 CG2 A:VAL81 3.6 75.2 1.0 CG A:ARG85 3.9 79.3 1.0 N A:ARG85 4.0 84.5 1.0 NH1 E:ARG105 4.0 92.2 1.0 CB A:PHE78 4.1 64.2 1.0 NH1 A:ARG85 4.1 57.9 1.0 O A:PHE78 4.1 69.3 1.0 CD2 A:PHE78 4.1 68.3 1.0 CA A:ARG77 4.2 71.9 1.0 CA A:PHE78 4.2 65.2 1.0 C A:ARG77 4.3 72.6 1.0 CA A:ALA84 4.3 92.5 1.0 CB A:ARG77 4.3 75.1 1.0 CB A:ARG85 4.6 77.2 1.0 CG A:PHE78 4.6 65.5 1.0 C A:PHE78 4.6 68.4 1.0 C A:ALA84 4.7 91.8 1.0 O A:ASN83 4.7 93.8 1.0 CG A:ARG77 4.8 85.0 1.0 CB A:VAL81 4.8 72.1 1.0 CD A:ARG85 4.9 80.6 1.0 CA A:ARG85 4.9 81.3 1.0 CB A:ALA84 5.0 96.7 1.0 CZ A:ARG85 5.0 87.6 1.0

Chlorine binding site 2 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl401 b:61.2 occ:1.00 N B:PHE78 3.4 43.6 1.0 CG2 B:VAL81 3.7 48.5 1.0 CG B:ARG85 3.8 70.2 1.0 NH1 B:ARG85 3.9 60.6 1.0 N B:ARG85 3.9 77.0 1.0 CD2 B:PHE78 3.9 50.5 1.0 CB B:PHE78 4.0 43.8 1.0 CA B:ARG77 4.1 47.0 1.0 CA B:PHE78 4.1 42.8 1.0 O B:PHE78 4.2 46.8 1.0 C B:ARG77 4.2 47.5 1.0 CA B:ALA84 4.4 81.3 1.0 NH1 A:ARG105 4.4 63.1 1.0 CB B:ARG77 4.4 49.4 1.0 CG B:PHE78 4.4 46.6 1.0 CB B:ARG85 4.4 70.0 1.0 C B:ALA84 4.7 84.0 1.0 C B:PHE78 4.7 45.5 1.0 CD B:ARG85 4.7 71.4 1.0 O B:ASN83 4.7 79.4 1.0 CZ B:ARG85 4.8 77.2 1.0 CA B:ARG85 4.8 75.5 1.0 CB B:VAL81 4.9 47.9 1.0 CG B:ARG77 4.9 63.7 1.0

Chlorine binding site 3 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl401 b:72.5 occ:1.00 N C:PHE78 3.5 68.3 1.0 CG2 C:VAL81 3.7 69.2 1.0 CG C:ARG85 3.9 81.0 1.0 N C:ARG85 3.9 87.4 1.0 NH1 B:ARG105 4.0 55.8 1.0 CB C:PHE78 4.1 68.0 1.0 NH1 C:ARG85 4.1 99.9 1.0 CD2 C:PHE78 4.2 75.1 1.0 O C:PHE78 4.2 68.1 1.0 CA C:ARG77 4.2 70.8 1.0 CA C:PHE78 4.3 67.2 1.0 CA C:ALA84 4.3 90.7 1.0 C C:ARG77 4.3 72.8 1.0 CB C:ARG77 4.4 72.5 1.0 CB C:ARG85 4.5 81.7 1.0 C C:ALA84 4.6 93.2 1.0 O C:ASN83 4.6 88.6 1.0 CG C:PHE78 4.6 71.2 1.0 C C:PHE78 4.7 68.3 1.0 CG C:ARG77 4.8 83.6 1.0 CD C:ARG85 4.8 88.5 1.0 CA C:ARG85 4.8 86.6 1.0 CB C:VAL81 4.9 67.8 1.0 CB C:ALA84 5.0 94.0 1.0

Chlorine binding site 4 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl402 b:82.1 occ:1.00 N D:PHE78 3.4 92.7 1.0 CG2 D:VAL81 3.7 90.4 1.0 NH1 C:ARG105 3.9 74.5 1.0 N D:ARG85 4.0 0.1 1.0 CG D:ARG85 4.0 0.3 1.0 NH1 D:ARG85 4.1 0.4 1.0 CB D:PHE78 4.1 89.9 1.0 O D:PHE78 4.1 92.5 1.0 CD2 D:PHE78 4.2 94.5 1.0 CA D:ARG77 4.2 99.5 1.0 CA D:ALA84 4.2 0.1 1.0 CA D:PHE78 4.2 90.5 1.0 C D:ARG77 4.3 0.5 1.0 CB D:ARG77 4.3 0.5 1.0 CB D:ARG85 4.6 98.5 1.0 C D:ALA84 4.6 0.1 1.0 CG D:PHE78 4.7 92.0 1.0 C D:PHE78 4.7 92.2 1.0 O D:ASN83 4.7 0.6 1.0 CG D:ARG77 4.8 1.0 1.0 CB D:VAL81 4.9 88.4 1.0 CB D:ALA84 4.9 0.1 1.0 CD D:ARG85 4.9 0.5 1.0 CA D:ARG85 4.9 0.3 1.0 CZ D:ARG85 5.0 0.3 1.0

Chlorine binding site 5 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193M within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl401 b:94.9 occ:1.00 N E:PHE78 3.4 92.5 1.0 CG2 E:VAL81 3.7 93.7 1.0 N E:ARG85 3.9 0.5 1.0 CG E:ARG85 3.9 98.0 1.0 NH1 E:ARG85 4.1 1.0 1.0 CB E:PHE78 4.1 90.6 1.0 O E:PHE78 4.2 98.9 1.0 CD2 E:PHE78 4.2 94.2 1.0 CA E:ARG77 4.2 97.1 1.0 CA E:ALA84 4.2 0.8 1.0 CA E:PHE78 4.2 91.7 1.0 C E:ARG77 4.3 98.0 1.0 CB E:ARG77 4.3 1.0 1.0 NH1 D:ARG105 4.6 0.2 1.0 CB E:ARG85 4.6 95.2 1.0 C E:ALA84 4.6 0.3 1.0 CG E:PHE78 4.7 91.5 1.0 O E:ASN83 4.7 0.9 1.0 C E:PHE78 4.7 97.7 1.0 CG E:ARG77 4.8 0.1 1.0 CB E:VAL81 4.9 91.3 1.0 CD E:ARG85 4.9 0.5 1.0 CA E:ARG85 4.9 98.7 1.0 CB E:ALA84 4.9 0.1 1.0

H.Hu, K.Ataka, A.Menny, Z.Fourati, L.Sauguet, P.J.Corringer, P.Koehl, J.Heberle, M.Delarue. Electrostatics, Proton Sensor, and Networks Governing the Gating Transition in Glic, A Proton-Gated Pentameric Ion Channel. Proc. Natl. Acad. Sci. V. 115 12172 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30541892
DOI: 10.1073/PNAS.1813378116