Chlorine in PDB 6hya: The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L

The structure of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L, PDB code: 6hya was solved by H.D.Hu, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.39
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	181.240, 133.320, 157.720, 90.00, 100.96, 90.00
R / Rfree (%)	18.4 / 21.2

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L (pdb code 6hya). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L, PDB code: 6hya:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:0.5 occ:1.00 NH1 A:ARG85 3.5 0.4 1.0 N A:PHE78 3.6 0.0 1.0 CD2 A:PHE78 3.6 0.6 1.0 CG A:ARG85 3.7 0.4 1.0 N A:ARG85 3.8 0.4 1.0 CG2 A:VAL81 3.8 0.1 1.0 NH1 E:ARG105 4.0 0.4 1.0 CB A:PHE78 4.1 0.9 1.0 CA A:ARG77 4.2 1.0 1.0 CA A:ALA84 4.2 0.6 1.0 CB A:ARG85 4.3 0.1 1.0 C A:ARG77 4.3 0.5 1.0 CG A:PHE78 4.3 0.7 1.0 CD A:ARG85 4.3 0.6 1.0 CA A:PHE78 4.4 0.0 1.0 CZ A:ARG85 4.4 0.5 1.0 CB A:ARG77 4.4 0.6 1.0 C A:ALA84 4.5 0.7 1.0 O A:PHE78 4.5 0.1 1.0 CE2 A:PHE78 4.6 1.0 1.0 CA A:ARG85 4.7 0.8 1.0 NE A:ARG85 4.7 0.3 1.0 CB A:ALA84 4.8 0.2 1.0 CB A:VAL81 4.9 0.1 1.0 CG A:ARG77 4.9 0.8 1.0 CG1 A:VAL81 4.9 0.4 1.0 C A:PHE78 5.0 0.4 1.0

Chlorine binding site 2 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl401 b:95.0 occ:1.00 N B:PHE78 3.3 86.9 1.0 CG2 B:VAL81 3.6 99.5 1.0 NH1 B:ARG85 3.7 0.2 1.0 CD2 B:PHE78 3.8 93.3 1.0 CA B:ARG77 4.0 89.0 1.0 N B:ARG85 4.0 0.1 1.0 CB B:PHE78 4.0 87.4 1.0 CG B:ARG85 4.1 0.4 1.0 C B:ARG77 4.1 89.4 1.0 NH1 A:ARG105 4.1 0.8 1.0 CA B:ALA84 4.2 0.8 1.0 CB B:ARG77 4.2 91.1 1.0 CA B:PHE78 4.2 86.1 1.0 O B:PHE78 4.2 87.6 1.0 CG B:PHE78 4.4 89.7 1.0 CB B:ALA84 4.6 0.5 1.0 C B:ALA84 4.6 0.3 1.0 CB B:ARG85 4.7 1.0 1.0 C B:PHE78 4.7 87.6 1.0 CZ B:ARG85 4.7 1.0 1.0 CG B:ARG77 4.7 0.7 1.0 CD B:ARG85 4.8 0.6 1.0 CB B:VAL81 4.8 98.0 1.0 CE2 B:PHE78 4.8 96.7 1.0 CG1 B:VAL81 5.0 96.7 1.0 CA B:ARG85 5.0 1.0 1.0

Chlorine binding site 3 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl401 b:0.5 occ:1.00 NH1 C:ARG85 3.5 0.9 1.0 N C:PHE78 3.5 97.0 1.0 CD2 C:PHE78 3.6 98.4 1.0 CG C:ARG85 3.6 0.5 1.0 N C:ARG85 3.7 0.1 1.0 CG2 C:VAL81 3.8 88.7 1.0 NH1 B:ARG105 4.1 0.6 1.0 CB C:PHE78 4.1 94.2 1.0 CA C:ARG77 4.2 0.7 1.0 CB C:ARG85 4.2 0.5 1.0 C C:ARG77 4.3 0.9 1.0 CA C:ALA84 4.3 0.3 1.0 CG C:PHE78 4.3 95.3 1.0 CD C:ARG85 4.3 0.9 1.0 CA C:PHE78 4.4 94.2 1.0 CB C:ARG77 4.4 1.0 1.0 CZ C:ARG85 4.5 0.4 1.0 C C:ALA84 4.5 0.1 1.0 O C:PHE78 4.5 99.1 1.0 CE2 C:PHE78 4.6 1.0 1.0 CA C:ARG85 4.6 0.3 1.0 NE C:ARG85 4.8 0.9 1.0 CB C:VAL81 4.9 86.5 1.0 CG C:ARG77 4.9 0.5 1.0 C C:PHE78 5.0 97.2 1.0 CB C:ALA84 5.0 0.9 1.0 CG1 C:VAL81 5.0 84.2 1.0

Chlorine binding site 4 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:0.1 occ:1.00 N D:PHE78 3.5 0.8 1.0 NH1 D:ARG85 3.5 0.3 1.0 CD2 D:PHE78 3.6 0.7 1.0 CG D:ARG85 3.7 0.7 1.0 N D:ARG85 3.8 0.2 1.0 CG2 D:VAL81 3.8 0.2 1.0 CB D:PHE78 4.1 0.8 1.0 CA D:ARG77 4.1 0.9 1.0 C D:ARG77 4.2 0.7 1.0 CA D:ALA84 4.2 0.6 1.0 CB D:ARG85 4.3 0.8 1.0 CA D:PHE78 4.3 0.5 1.0 NH1 C:ARG105 4.3 0.2 1.0 CG D:PHE78 4.3 0.8 1.0 CB D:ARG77 4.4 0.7 1.0 CD D:ARG85 4.4 0.5 1.0 O D:PHE78 4.5 0.1 1.0 CZ D:ARG85 4.5 0.8 1.0 C D:ALA84 4.5 1.0 1.0 CE2 D:PHE78 4.6 0.4 1.0 CA D:ARG85 4.7 0.1 1.0 CB D:ALA84 4.8 0.9 1.0 NE D:ARG85 4.8 0.1 1.0 CG D:ARG77 4.9 1.0 1.0 C D:PHE78 4.9 0.5 1.0 CB D:VAL81 4.9 1.0 1.0 CG1 D:VAL81 5.0 0.3 1.0

Chlorine binding site 5 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel Mutant Q193L within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl401 b:0.8 occ:1.00 NH1 E:ARG85 3.5 0.3 1.0 N E:PHE78 3.5 0.0 1.0 CD2 E:PHE78 3.6 0.2 1.0 CG E:ARG85 3.6 0.9 1.0 N E:ARG85 3.8 0.3 1.0 CG2 E:VAL81 3.9 0.6 1.0 CB E:PHE78 4.1 0.6 1.0 CA E:ARG77 4.1 0.8 1.0 CA E:ALA84 4.2 0.5 1.0 C E:ARG77 4.2 0.6 1.0 CB E:ARG85 4.3 0.3 1.0 CG E:PHE78 4.3 0.6 1.0 CD E:ARG85 4.3 0.7 1.0 CA E:PHE78 4.3 0.5 1.0 CB E:ARG77 4.4 0.6 1.0 CZ E:ARG85 4.4 0.0 1.0 C E:ALA84 4.5 0.6 1.0 O E:PHE78 4.5 0.6 1.0 CE2 E:PHE78 4.5 0.6 1.0 CA E:ARG85 4.6 0.1 1.0 NH1 D:ARG105 4.7 0.6 1.0 NE E:ARG85 4.7 0.6 1.0 CB E:ALA84 4.8 0.2 1.0 CG E:ARG77 4.9 0.8 1.0 C E:PHE78 5.0 1.0 1.0 CB E:VAL81 5.0 0.3 1.0

H.Hu, K.Ataka, A.Menny, Z.Fourati, L.Sauguet, P.J.Corringer, P.Koehl, J.Heberle, M.Delarue. Electrostatics, Proton Sensor, and Networks Governing the Gating Transition in Glic, A Proton-Gated Pentameric Ion Channel. Proc. Natl. Acad. Sci. V. 115 12172 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30541892
DOI: 10.1073/PNAS.1813378116