Chlorine in PDB 6hz3: The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G

The structure of The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G, PDB code: 6hz3 was solved by H.D.Hu, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.15
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.450, 129.070, 159.610, 90.00, 101.03, 90.00
R / Rfree (%)	23 / 24.9

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G (pdb code 6hz3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G, PDB code: 6hz3:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:32.3 occ:1.00 NH1 A:ARG85 3.3 30.3 1.0 N A:PHE78 3.4 24.9 1.0 N A:ARG85 3.7 40.2 1.0 CA A:ALA84 3.9 40.2 1.0 CD2 A:PHE78 3.9 32.2 1.0 CG A:ARG85 3.9 30.9 1.0 CB A:PHE78 4.0 26.4 1.0 CG2 A:VAL81 4.0 33.4 1.0 CA A:ARG77 4.1 22.4 1.0 CA A:PHE78 4.2 24.9 1.0 CB A:ALA84 4.2 42.1 1.0 C A:ARG77 4.2 25.8 1.0 O A:PHE78 4.3 28.5 1.0 CB A:ARG77 4.3 21.7 1.0 C A:ALA84 4.3 43.8 1.0 CB A:ARG85 4.3 36.4 1.0 CD A:ARG85 4.4 27.9 1.0 CG A:PHE78 4.5 28.6 1.0 CZ A:ARG85 4.5 38.2 1.0 NH1 E:ARG105 4.6 45.4 1.0 CG A:ARG77 4.6 31.5 1.0 CA A:ARG85 4.6 39.9 1.0 C A:PHE78 4.7 28.7 1.0 NE A:ARG85 4.9 34.2 1.0

Chlorine binding site 2 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl401 b:37.2 occ:1.00 NH1 B:ARG85 3.4 41.9 1.0 N B:PHE78 3.4 22.5 1.0 N B:ARG85 3.6 36.9 1.0 O B:HOH508 3.7 8.8 1.0 CA B:ALA84 3.9 43.9 1.0 CD2 B:PHE78 3.9 29.5 1.0 CG B:ARG85 4.0 32.1 1.0 CG2 B:VAL81 4.0 25.0 1.0 CB B:PHE78 4.0 23.5 1.0 CA B:ARG77 4.1 22.8 1.0 CB B:ALA84 4.2 45.4 1.0 CA B:PHE78 4.2 21.8 1.0 C B:ARG77 4.3 26.5 1.0 O B:PHE78 4.3 23.0 1.0 CB B:ARG77 4.3 24.7 1.0 C B:ALA84 4.3 44.7 1.0 CB B:ARG85 4.3 30.2 1.0 CD B:ARG85 4.5 35.6 1.0 CG B:PHE78 4.5 25.9 1.0 CZ B:ARG85 4.5 58.4 1.0 NH1 A:ARG105 4.6 45.9 1.0 CA B:ARG85 4.6 34.6 1.0 CG B:ARG77 4.6 37.9 1.0 C B:PHE78 4.8 23.1 1.0 NE B:ARG85 4.9 44.7 1.0

Chlorine binding site 3 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl401 b:25.6 occ:1.00 N C:PHE78 3.3 20.3 1.0 NH1 C:ARG85 3.4 18.2 1.0 N C:ARG85 3.6 26.0 1.0 CD2 C:PHE78 3.9 26.2 1.0 CA C:ALA84 3.9 29.1 1.0 CB C:PHE78 4.0 21.3 1.0 CG2 C:VAL81 4.0 23.2 1.0 CG C:ARG85 4.0 22.7 1.0 CA C:ARG77 4.1 15.9 1.0 CA C:PHE78 4.2 20.3 1.0 C C:ARG77 4.2 21.4 1.0 O C:PHE78 4.2 23.9 1.0 NH1 B:ARG105 4.2 52.2 1.0 CB C:ARG77 4.3 14.7 1.0 CB C:ALA84 4.3 30.5 1.0 C C:ALA84 4.3 31.7 1.0 CB C:ARG85 4.3 22.8 1.0 CG C:PHE78 4.4 22.9 1.0 CD C:ARG85 4.5 20.7 1.0 CZ C:ARG85 4.6 27.1 1.0 CA C:ARG85 4.6 25.5 1.0 CG C:ARG77 4.6 20.4 1.0 C C:PHE78 4.7 22.9 1.0 NE C:ARG85 5.0 23.8 1.0 CE2 C:PHE78 5.0 29.4 1.0

Chlorine binding site 4 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl401 b:26.0 occ:1.00 NH1 D:ARG85 3.4 27.7 1.0 N D:PHE78 3.4 22.7 1.0 N D:ARG85 3.7 35.5 1.0 CA D:ALA84 3.9 35.6 1.0 CD2 D:PHE78 4.0 27.7 1.0 CG D:ARG85 4.0 34.5 1.0 CB D:PHE78 4.0 22.7 1.0 CG2 D:VAL81 4.0 28.6 1.0 CA D:ARG77 4.1 22.7 1.0 CB D:ALA84 4.2 37.3 1.0 CA D:PHE78 4.2 21.8 1.0 CB D:ARG77 4.2 21.7 1.0 C D:ARG77 4.2 26.2 1.0 O D:PHE78 4.3 24.7 1.0 C D:ALA84 4.3 39.4 1.0 CB D:ARG85 4.4 32.7 1.0 CD D:ARG85 4.5 32.8 1.0 CG D:PHE78 4.5 24.6 1.0 CZ D:ARG85 4.5 38.8 1.0 CG D:ARG77 4.6 29.9 1.0 CA D:ARG85 4.7 34.9 1.0 C D:PHE78 4.8 25.4 1.0 NH1 C:ARG105 4.9 44.0 1.0 NE D:ARG85 4.9 36.1 1.0

Chlorine binding site 5 out of 5 in the The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel Mutant E243G within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl401 b:34.9 occ:1.00 N E:PHE78 3.3 27.4 1.0 NH1 E:ARG85 3.3 23.1 1.0 N E:ARG85 3.8 30.5 1.0 CA E:ARG77 3.9 28.3 1.0 CD2 E:PHE78 3.9 28.2 1.0 CB E:PHE78 4.0 26.6 1.0 CA E:ALA84 4.0 34.0 1.0 C E:ARG77 4.1 31.1 1.0 CB E:ARG77 4.1 29.3 1.0 CG E:ARG85 4.1 27.9 1.0 CG2 E:VAL81 4.1 27.2 1.0 CA E:PHE78 4.1 26.4 1.0 O E:PHE78 4.2 28.8 1.0 CB E:ALA84 4.3 35.7 1.0 CG E:ARG77 4.4 39.5 1.0 CG E:PHE78 4.4 27.1 1.0 NH1 D:ARG105 4.5 41.6 1.0 C E:ALA84 4.5 35.6 1.0 CB E:ARG85 4.5 27.3 1.0 CZ E:ARG85 4.5 32.7 1.0 CD E:ARG85 4.5 28.3 1.0 C E:PHE78 4.7 28.5 1.0 CA E:ARG85 4.8 29.7 1.0 NE E:ARG85 4.9 29.4 1.0 CE2 E:PHE78 5.0 30.1 1.0

H.Hu, K.Ataka, A.Menny, Z.Fourati, L.Sauguet, P.J.Corringer, P.Koehl, J.Heberle, M.Delarue. Electrostatics, Proton Sensor, and Networks Governing the Gating Transition in Glic, A Proton-Gated Pentameric Ion Channel. Proc. Natl. Acad. Sci. V. 115 12172 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30541892
DOI: 10.1073/PNAS.1813378116