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Chlorine in PDB 6i0c: Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor.
Enzymatic activity of Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor.
All present enzymatic activity of Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor.:
3.1.1.8;
3.1.1.8;
Protein crystallography data
The structure of Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor., PDB code: 6i0c
was solved by
X.Brazzolotto,
F.Nachon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 98.67 / 2.68 |
| Space group | I 4 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 154.608, 154.608, 128.173, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19 / 25.2 |
Other elements in 6i0c:
The structure of Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor. also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor.
(pdb code 6i0c). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor., PDB code: 6i0c:
In total only one binding site of Chlorine was determined in the Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor., PDB code: 6i0c:
Chlorine binding site 1 out of 1 in 6i0c
Go back to
Chlorine Binding Sites List in 6i0c
Chlorine binding site 1 out
of 1 in the Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Human Butyrylcholinesterase in Complex with the R Enantiomer of A Chlorotacrine-Tryptophan Multi-Target Inhibitor. within 5.0Å range:
|
Reference:
K.Chalupova,
J.Korabecny,
M.Bartolini,
B.Monti,
D.Lamba,
R.Caliandro,
A.Pesaresi,
X.Brazzolotto,
A.J.Gastellier,
F.Nachon,
J.Pejchal,
M.Jarosova,
V.Hepnarova,
D.Jun,
M.Hrabinova,
R.Dolezal,
J.Zdarova Karasova,
M.Mzik,
Z.Kristofikova,
J.Misik,
L.Muckova,
P.Jost,
O.Soukup,
M.Benkova,
V.Setnicka,
L.Habartova,
M.Chvojkova,
L.Kleteckova,
K.Vales,
E.Mezeiova,
E.Uliassi,
M.Valis,
E.Nepovimova,
M.L.Bolognesi,
K.Kuca.
Novel Tacrine-Tryptophan Hybrids: Multi-Target Directed Ligands As Potential Treatment For Alzheimer'S Disease. Eur.J.Med.Chem. V. 168 491 2019.
ISSN: ISSN 0223-5234
PubMed: 30851693
DOI: 10.1016/J.EJMECH.2019.02.021
Page generated: Sun Jul 28 01:28:54 2024
ISSN: ISSN 0223-5234
PubMed: 30851693
DOI: 10.1016/J.EJMECH.2019.02.021
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