Chlorine in PDB 6ipf: Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP

Enzymatic activity of Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP

All present enzymatic activity of Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP:
2.7.7.7;

Protein crystallography data

The structure of Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP, PDB code: 6ipf was solved by Y.K.Chang, W.J.Wu, M.D.Tsai, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.77
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 59.778, 68.792, 109.620, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 21.8

Other elements in 6ipf:

The structure of Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP also contains other interesting chemical elements:

Manganese (Mn) 4 atoms
Sodium (Na) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP (pdb code 6ipf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP, PDB code: 6ipf:

Chlorine binding site 1 out of 1 in 6ipf

Go back to Chlorine Binding Sites List in 6ipf
Chlorine binding site 1 out of 1 in the Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Post-Catalytic Complex of Human Dna Polymerase Mu with Templating Cytosine and Mn-8OXODGMP within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl506

b:68.4
occ:1.00
NE2 A:HIS219 2.6 56.1 1.0
OE2 A:GLU218 3.0 65.5 1.0
CD2 A:HIS219 3.5 53.7 1.0
CE1 A:HIS219 3.6 56.2 1.0
CD A:GLU218 3.7 60.6 1.0
OE1 A:GLU218 4.0 64.1 1.0
CB A:GLU218 4.7 49.3 1.0
CG A:HIS219 4.7 52.5 1.0
ND1 A:HIS219 4.7 54.9 1.0
CG A:GLU218 4.8 55.0 1.0

Reference:

Y.K.Chang, Y.P.Huang, X.X.Liu, T.P.Ko, Y.Bessho, Y.Kawano, M.Maestre-Reyna, W.J.Wu, M.D.Tsai. Human Dna Polymerase Mu Can Use A Noncanonical Mechanism For Multiple MN2+-Mediated Functions. J.Am.Chem.Soc. V. 141 8489 2019.
ISSN: ESSN 1520-5126
PubMed: 31067051
DOI: 10.1021/JACS.9B01741
Page generated: Sat Dec 12 13:10:28 2020

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