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Chlorine in PDB 6jxt: Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization

Enzymatic activity of Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization

All present enzymatic activity of Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization, PDB code: 6jxt was solved by C.H.Yun, S.J.Zhu, X.E.Yan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.38 / 2.31
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 86.749, 86.749, 103.939, 90.00, 90.00, 120.00
R / Rfree (%) 21.7 / 23.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization (pdb code 6jxt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization, PDB code: 6jxt:

Chlorine binding site 1 out of 1 in 6jxt

Go back to Chlorine Binding Sites List in 6jxt
Chlorine binding site 1 out of 1 in the Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Egfr 696-1022 Wt in Complex with AZD9291 Prepared By Cocrystallization within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1102

b:86.8
occ:1.00
O A:HOH1249 3.6 60.4 1.0
NH1 A:ARG803 3.8 43.1 1.0
NH2 A:ARG803 3.8 50.5 1.0
O A:HOH1235 4.2 49.2 1.0
CD A:LYS913 4.2 75.4 1.0
CZ A:ARG803 4.3 49.5 1.0
CD2 A:LEU799 4.6 44.8 1.0
CE A:LYS913 4.8 81.0 1.0
CG A:LYS913 4.9 63.3 1.0

Reference:

C.H.Yun, S.J.Zhu, X.E.Yan. Structural Basis of the Selectivity of the Drug Molecule AZD9291 For the T790M Cancer Mutant of Egfr To Be Published.
Page generated: Sun Jul 28 02:21:15 2024

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