Chlorine in PDB 6l3x: Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Enzymatic activity of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
All present enzymatic activity of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo:
3.4.21.92;
3.4.21.92;
Protein crystallography data
The structure of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo, PDB code: 6l3x
was solved by
Y.F.Luo,
R.Bao,
Y.Ju,
L.H.He,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.11 / 2.31 |
| Space group | P 32 |
| Cell size a, b, c (Å), α, β, γ (°) | 176.750, 176.750, 101.200, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 19 / 21.7 |
Chlorine Binding Sites:
Pages:
>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;Binding sites:
The binding sites of Chlorine atom in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo (pdb code 6l3x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.In total 28 binding sites of Chlorine where determined in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo, PDB code: 6l3x:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
Chlorine binding site 1 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 1 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 2 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 2 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 3 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 3 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 4 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 4 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 5 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 5 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 6 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 6 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 7 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 7 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 8 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 8 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 9 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 9 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 9 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Chlorine binding site 10 out of 28 in 6l3x
Go back to
Chlorine Binding Sites List in 6l3x
Chlorine binding site 10 out
of 28 in the Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 10 of Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockers in Vitro and in Vivo within 5.0Å range:
|
Reference:
Y.Ju,
L.He,
Y.Zhou,
T.Yang,
K.Sun,
R.Song,
Y.Yang,
C.Li,
Z.Sang,
R.Bao,
Y.Luo.
Discovery of Novel Peptidomimetic Boronate Clpp Inhibitors with Noncanonical Enzyme Mechanism As Potent Virulence Blockersin Vitroandin Vivo. J.Med.Chem. V. 63 3104 2020.
ISSN: ISSN 0022-2623
PubMed: 32031798
DOI: 10.1021/ACS.JMEDCHEM.9B01746
Page generated: Sat Dec 12 13:16:01 2020
ISSN: ISSN 0022-2623
PubMed: 32031798
DOI: 10.1021/ACS.JMEDCHEM.9B01746
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