Chlorine in PDB 6lsn: Crystal Structure of Tubulin-Inhibitor Complex

The structure of Crystal Structure of Tubulin-Inhibitor Complex, PDB code: 6lsn was solved by L.Gang, Y.X.Wang, J.J.Cheng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.17 / 2.45
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	105.296, 158.458, 181.959, 90, 90, 90
R / Rfree (%)	17.7 / 22

The structure of Crystal Structure of Tubulin-Inhibitor Complex also contains other interesting chemical elements:

Calcium	(Ca)	4 atoms
Magnesium	(Mg)	6 atoms

The binding sites of Chlorine atom in the Crystal Structure of Tubulin-Inhibitor Complex (pdb code 6lsn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Tubulin-Inhibitor Complex, PDB code: 6lsn:

Chlorine binding site 1 out of 1 in the Crystal Structure of Tubulin-Inhibitor Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Tubulin-Inhibitor Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl504 b:76.1 occ:1.00 N A:LYS163 3.2 82.7 1.0 NZ A:LYS164 3.3 95.5 1.0 N A:GLY162 3.4 59.5 1.0 CD A:LYS164 3.6 67.0 1.0 C A:TYR161 3.6 62.2 1.0 CB A:LYS163 3.7 92.5 1.0 CA A:TYR161 3.8 63.4 1.0 CE A:LYS164 3.9 82.8 1.0 CA A:LYS163 4.0 90.2 1.0 CG A:LYS163 4.1 97.6 1.0 O A:TYR161 4.2 70.9 1.0 C A:GLY162 4.2 72.9 1.0 CA A:GLY162 4.3 68.4 1.0 N A:LYS164 4.5 73.5 1.0 CB A:TYR161 4.6 57.7 1.0 C A:LYS163 4.6 82.9 1.0 N A:TYR161 4.9 68.6 1.0 CG A:LYS164 4.9 62.1 1.0 O A:ASP160 4.9 63.9 1.0

L.Gang, Y.X.Wang, J.J.Chen. Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-A]Pyrimidine Derivatives As Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published.