Chlorine in PDB 6luq: Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands

Enzymatic activity of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands

All present enzymatic activity of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands:
3.2.1.17;

Protein crystallography data

The structure of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands, PDB code: 6luq was solved by L.Fan, L.Tan, Z.Chen, J.Qi, F.Nie, Z.Luo, J.Cheng, S.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.39 / 3.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.433, 72.820, 150.269, 90.00, 90.00, 90.00
R / Rfree (%) 21.5 / 22.9

Other elements in 6luq:

The structure of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands also contains other interesting chemical elements:

Fluorine (F) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands (pdb code 6luq). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands, PDB code: 6luq:

Chlorine binding site 1 out of 1 in 6luq

Go back to Chlorine Binding Sites List in 6luq
Chlorine binding site 1 out of 1 in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1201

b:0.1
occ:1.00
 CL1 A:GMJ1201 0.0 0.1 1.0
C21 A:GMJ1201 1.7 0.9 1.0
C22 A:GMJ1201 2.6 0.6 1.0
C20 A:GMJ1201 2.7 0.3 1.0
CD2 A:LEU94 3.4 59.6 1.0
C23 A:GMJ1201 3.9 0.7 1.0
C19 A:GMJ1201 4.0 0.8 1.0
SG A:CYS107 4.0 34.5 0.5
CE2 A:PHE110 4.4 73.4 1.0
CD1 A:LEU94 4.4 66.4 1.0
C18 A:GMJ1201 4.5 93.2 1.0
CG A:LEU94 4.5 65.0 1.0
CG2 A:ILE184 4.6 76.5 1.0
CE3 A:TRP100 4.8 62.9 1.0
CD2 A:PHE110 4.9 89.8 1.0

Reference:

L.Fan, L.Tan, Z.Chen, J.Qi, F.Nie, Z.Luo, J.Cheng, S.Wang. Haloperidol Bound D2 Dopamine Receptor Structure Inspired the Discovery of Subtype Selective Ligands Nat Commun 2020.
ISSN: ESSN 2041-1723
Page generated: Sun Jul 28 02:57:55 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy