Atomistry » Chlorine » PDB 6lw2-6m7z » 6lw2
Atomistry »
  Chlorine »
    PDB 6lw2-6m7z »
      6lw2 »

Chlorine in PDB 6lw2: The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase

Enzymatic activity of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase

All present enzymatic activity of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase:
3.1.3.11;

Protein crystallography data

The structure of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase, PDB code: 6lw2 was solved by X.Y.Wang, J.Zhou, B.L.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.95 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.315, 83.595, 280.338, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 29

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase (pdb code 6lw2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase, PDB code: 6lw2:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 6lw2

Go back to Chlorine Binding Sites List in 6lw2
Chlorine binding site 1 out of 4 in the The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:61.9
occ:1.00
CL1 A:EW0401 0.0 61.9 1.0
C10 A:EW0401 1.8 63.1 1.0
C11 A:EW0401 2.7 66.0 1.0
C9 A:EW0401 2.8 64.6 1.0
C15 A:EW0401 3.2 55.9 1.0
N2 A:EW0401 3.4 59.9 1.0
CA D:GLY28 3.5 52.5 1.0
N2 D:EW0401 3.6 66.0 1.0
C15 D:EW0401 3.7 58.5 1.0
C13 D:EW0401 3.8 59.5 1.0
O D:THR27 3.9 53.1 1.0
C11 D:EW0401 3.9 72.5 1.0
CE A:MET18 4.0 58.6 1.0
C12 A:EW0401 4.1 61.8 1.0
C8 A:EW0401 4.1 68.0 1.0
CG A:ARG22 4.2 56.8 1.0
N D:GLY28 4.2 56.8 1.0
C14 D:EW0401 4.3 64.3 1.0
CD A:ARG22 4.3 50.7 1.0
C D:THR27 4.3 55.0 1.0
C12 D:EW0401 4.4 71.9 1.0
C D:GLY28 4.4 47.9 1.0
C16 D:EW0401 4.4 58.2 1.0
C10 D:EW0401 4.5 74.6 1.0
O D:GLY28 4.5 46.0 1.0
CB A:ARG22 4.5 52.0 1.0
C7 A:EW0401 4.6 64.4 1.0
C13 A:EW0401 4.7 52.3 1.0
O A:MET18 4.8 51.7 1.0
N3 D:EW0401 4.9 55.6 1.0
CL1 D:EW0401 4.9 74.8 1.0
CG A:MET18 5.0 54.1 1.0

Chlorine binding site 2 out of 4 in 6lw2

Go back to Chlorine Binding Sites List in 6lw2
Chlorine binding site 2 out of 4 in the The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl401

b:51.2
occ:1.00
CL1 B:EW0401 0.0 51.2 1.0
C10 B:EW0401 1.8 58.3 1.0
C11 B:EW0401 2.8 53.3 1.0
C9 B:EW0401 2.8 56.6 1.0
CA C:GLY28 3.2 50.2 1.0
C15 B:EW0401 3.3 44.0 1.0
N2 B:EW0401 3.4 54.2 1.0
N2 C:EW0401 3.8 52.7 1.0
C15 C:EW0401 3.8 49.3 1.0
N C:GLY28 4.0 49.9 1.0
C13 C:EW0401 4.0 54.2 1.0
C12 B:EW0401 4.1 54.7 1.0
C8 B:EW0401 4.1 57.2 1.0
C11 C:EW0401 4.3 54.4 1.0
CG B:ARG22 4.3 60.4 1.0
C C:GLY28 4.4 41.4 1.0
SD B:MET18 4.4 76.2 1.0
C16 C:EW0401 4.4 46.7 1.0
O C:THR27 4.5 44.4 1.0
CB B:ARG22 4.5 57.1 1.0
O C:GLY28 4.5 46.3 1.0
C C:THR27 4.6 46.4 1.0
C14 C:EW0401 4.6 54.9 1.0
C7 B:EW0401 4.6 56.9 1.0
O1 C:EW0401 4.7 42.3 1.0
O B:MET18 4.7 53.0 1.0
C13 B:EW0401 4.7 55.6 1.0
C12 C:EW0401 4.8 56.7 1.0
C10 C:EW0401 4.9 56.5 1.0

Chlorine binding site 3 out of 4 in 6lw2

Go back to Chlorine Binding Sites List in 6lw2
Chlorine binding site 3 out of 4 in the The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl401

b:58.8
occ:1.00
CL1 C:EW0401 0.0 58.8 1.0
C10 C:EW0401 1.8 56.5 1.0
C11 C:EW0401 2.7 54.4 1.0
C9 C:EW0401 2.8 57.6 1.0
C15 C:EW0401 3.2 49.3 1.0
NH1 C:ARG22 3.3 69.8 1.0
N2 C:EW0401 3.4 52.7 1.0
CA B:GLY28 3.4 43.8 1.0
N2 B:EW0401 3.8 54.2 1.0
C15 B:EW0401 4.0 44.0 1.0
C12 C:EW0401 4.1 56.7 1.0
N B:GLY28 4.1 49.8 1.0
C8 C:EW0401 4.1 61.1 1.0
C13 B:EW0401 4.1 55.6 1.0
C11 B:EW0401 4.2 53.3 1.0
CG C:MET18 4.2 63.9 1.0
O B:THR27 4.3 53.1 1.0
CG C:ARG22 4.4 57.2 1.0
CZ C:ARG22 4.4 66.7 1.0
C B:THR27 4.4 46.1 1.0
C14 B:EW0401 4.5 53.7 1.0
C12 B:EW0401 4.6 54.7 1.0
C7 C:EW0401 4.6 56.8 1.0
C16 B:EW0401 4.6 43.2 1.0
CB C:ARG22 4.6 54.5 1.0
C B:GLY28 4.6 41.7 1.0
SD C:MET18 4.7 66.5 1.0
C13 C:EW0401 4.7 54.2 1.0
C10 B:EW0401 4.7 58.3 1.0
O C:MET18 4.8 51.8 1.0
O B:GLY28 4.9 45.6 1.0
O1 B:EW0401 4.9 41.3 1.0
CD C:ARG22 4.9 59.5 1.0
C14 C:EW0401 5.0 54.9 1.0

Chlorine binding site 4 out of 4 in 6lw2

Go back to Chlorine Binding Sites List in 6lw2
Chlorine binding site 4 out of 4 in the The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl401

b:74.8
occ:1.00
CL1 D:EW0401 0.0 74.8 1.0
C10 D:EW0401 1.8 74.6 1.0
C11 D:EW0401 2.7 72.5 1.0
C9 D:EW0401 2.8 71.7 1.0
CE D:MET18 3.2 67.4 1.0
C15 D:EW0401 3.3 58.5 1.0
CA A:GLY28 3.3 33.9 1.0
N2 D:EW0401 3.4 66.0 1.0
N2 A:EW0401 3.7 59.9 1.0
C15 A:EW0401 3.7 55.9 1.0
CG D:ARG22 3.9 72.0 1.0
C13 A:EW0401 4.0 52.3 1.0
C12 D:EW0401 4.1 71.9 1.0
C11 A:EW0401 4.1 66.0 1.0
C8 D:EW0401 4.1 72.2 1.0
N A:GLY28 4.1 38.3 1.0
CB D:ARG22 4.2 68.4 1.0
O A:THR27 4.3 49.0 1.0
O D:MET18 4.4 53.7 1.0
C A:GLY28 4.5 38.4 1.0
C16 A:EW0401 4.5 47.8 1.0
C A:THR27 4.5 44.6 1.0
C14 A:EW0401 4.5 51.9 1.0
O A:GLY28 4.6 36.3 1.0
C7 D:EW0401 4.6 74.3 1.0
C10 A:EW0401 4.6 63.1 1.0
C12 A:EW0401 4.6 61.8 1.0
C13 D:EW0401 4.7 59.5 1.0
O1 A:EW0401 4.7 40.2 1.0
CL1 A:EW0401 4.9 61.9 1.0
SD D:MET18 5.0 71.9 1.0
C14 D:EW0401 5.0 64.3 1.0

Reference:

X.Y.Wang, J.Zhou, B.L.Xu. The N-Arylsulfonyl-Indole-2-Carboxamide-Based Inhibitors Against Fructose-1,6-Bisphosphatase To Be Published.
Page generated: Sat Jul 12 16:37:05 2025

Last articles

Cl in 6S7H
Cl in 6S6J
Cl in 6S6C
Cl in 6S7D
Cl in 6S69
Cl in 6S66
Cl in 6S6F
Cl in 6S64
Cl in 6S4Q
Cl in 6S4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy