Chlorine in PDB 6m8q: Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531

The structure of Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531, PDB code: 6m8q was solved by W.A.Weihofen, M.Salcius, G.Michaud, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	73.95 / 2.49
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	106.222, 106.222, 206.035, 90.00, 90.00, 90.00
R / Rfree (%)	16.3 / 22.1

The structure of Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531 also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Chlorine atom in the Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531 (pdb code 6m8q). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531, PDB code: 6m8q:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:67.4 occ:1.00 CL17 A:JBG503 0.0 67.4 1.0 C16 A:JBG503 1.8 57.6 1.0 C11 A:JBG503 2.7 55.3 1.0 C15 A:JBG503 2.8 51.2 1.0 O9 A:JBG503 3.0 54.3 1.0 O19 A:JBG503 3.0 49.0 1.0 CB A:PRO329 3.4 37.5 1.0 CB A:MET331 3.4 40.9 1.0 C8 A:JBG503 3.5 57.1 1.0 N A:MET331 3.6 37.6 1.0 CG A:PRO329 3.6 42.0 1.0 CG A:GLN333 3.7 60.7 1.0 CA A:MET331 3.8 38.3 1.0 C A:MET331 3.9 43.3 1.0 CB A:GLN333 3.9 45.8 1.0 N A:MET332 3.9 41.6 1.0 N A:GLN333 3.9 45.1 1.0 C12 A:JBG503 4.1 51.7 1.0 C14 A:JBG503 4.1 48.5 1.0 C7 A:JBG503 4.3 60.4 1.0 CG A:MET331 4.3 46.1 1.0 N A:GLY330 4.5 35.9 1.0 CA A:PRO329 4.6 36.1 1.0 CA A:GLN333 4.6 44.9 1.0 C A:PRO329 4.6 39.0 1.0 O A:MET331 4.6 40.9 1.0 C13 A:JBG503 4.6 47.9 1.0 CE2 A:PHE241 4.7 43.4 1.0 C A:GLY330 4.8 41.2 1.0 CA A:MET332 4.8 42.1 1.0 C A:MET332 4.9 47.0 1.0 CD A:PRO329 5.0 38.6 1.0

Chlorine binding site 2 out of 4 in the Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:48.5 occ:1.00 CL18 A:JBG503 0.0 48.5 1.0 C12 A:JBG503 1.7 51.7 1.0 C11 A:JBG503 2.7 55.3 1.0 C13 A:JBG503 2.7 47.9 1.0 O9 A:JBG503 2.9 54.3 1.0 CD1 A:ILE43 2.9 52.0 1.0 CE1 A:TYR110 3.5 41.0 1.0 C8 A:JBG503 3.6 57.1 1.0 CG A:PRO45 3.6 48.3 1.0 CB A:PRO45 3.7 44.9 1.0 CA A:PRO45 3.7 42.5 1.0 C5 A:JBG503 3.9 59.1 1.0 C6 A:JBG503 4.0 60.7 1.0 C14 A:JBG503 4.0 48.5 1.0 C16 A:JBG503 4.0 57.6 1.0 CD1 A:LEU74 4.1 35.7 1.0 CD1 A:TYR110 4.2 42.1 1.0 N4 A:JBG503 4.2 60.2 1.0 N A:PRO45 4.2 41.6 1.0 CB A:LEU74 4.3 30.7 1.0 CZ A:TYR110 4.3 51.1 1.0 CG1 A:ILE43 4.3 46.0 1.0 OH A:TYR110 4.4 57.0 1.0 CD A:PRO45 4.5 43.0 1.0 C7 A:JBG503 4.5 60.4 1.0 C15 A:JBG503 4.5 51.2 1.0 CG A:LEU74 4.8 35.5 1.0 C A:HIS44 4.9 42.3 1.0

Chlorine binding site 3 out of 4 in the Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl503 b:71.8 occ:1.00 CL17 B:JBG503 0.0 71.8 1.0 C16 B:JBG503 1.8 61.0 1.0 C11 B:JBG503 2.7 56.7 1.0 C15 B:JBG503 2.7 54.6 1.0 O19 B:JBG503 2.9 51.2 1.0 O9 B:JBG503 3.0 53.7 1.0 CB B:PRO329 3.4 40.1 1.0 CB B:MET331 3.5 40.6 1.0 N B:MET331 3.5 39.5 1.0 C8 B:JBG503 3.5 53.6 1.0 CG B:PRO329 3.6 44.5 1.0 CA B:MET331 3.7 39.4 1.0 N B:MET332 3.9 42.5 1.0 C B:MET331 3.9 46.0 1.0 N B:GLN333 4.0 46.3 1.0 C12 B:JBG503 4.0 54.6 1.0 C14 B:JBG503 4.1 54.1 1.0 CG B:GLN333 4.1 47.0 1.0 CB B:GLN333 4.1 48.2 1.0 C7 B:JBG503 4.3 53.4 1.0 CG B:MET331 4.4 41.9 1.0 N B:GLY330 4.4 37.3 1.0 C B:PRO329 4.5 41.4 1.0 CA B:PRO329 4.5 38.3 1.0 C13 B:JBG503 4.6 53.5 1.0 C B:GLY330 4.6 41.9 1.0 O B:MET331 4.7 47.1 1.0 CA B:GLN333 4.7 46.7 1.0 CE2 B:PHE241 4.7 46.0 1.0 CA B:MET332 4.8 42.7 1.0 C B:MET332 4.9 49.7 1.0

Chlorine binding site 4 out of 4 in the Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in Complex with Nvp-LTM531 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl503 b:54.8 occ:1.00 CL18 B:JBG503 0.0 54.8 1.0 C12 B:JBG503 1.7 54.6 1.0 C13 B:JBG503 2.7 53.5 1.0 C11 B:JBG503 2.7 56.7 1.0 CD1 B:ILE43 2.9 58.2 1.0 O9 B:JBG503 3.0 53.7 1.0 CE1 B:TYR110 3.5 48.9 1.0 C8 B:JBG503 3.6 53.6 1.0 CB B:PRO45 3.8 44.8 1.0 CA B:PRO45 3.9 43.6 1.0 CG B:PRO45 4.0 48.6 1.0 C16 B:JBG503 4.0 61.0 1.0 C14 B:JBG503 4.0 54.1 1.0 CD1 B:LEU74 4.1 40.4 1.0 CB B:LEU74 4.1 36.8 1.0 CD1 B:TYR110 4.1 48.9 1.0 CG1 B:ILE43 4.2 48.7 1.0 CZ B:TYR110 4.2 56.7 1.0 C5 B:JBG503 4.3 51.4 1.0 N4 B:JBG503 4.3 51.4 1.0 C6 B:JBG503 4.3 54.1 1.0 OH B:TYR110 4.4 58.9 1.0 N B:PRO45 4.4 43.9 1.0 C15 B:JBG503 4.5 54.6 1.0 C7 B:JBG503 4.6 53.4 1.0 CG B:LEU74 4.6 40.8 1.0 CD B:PRO45 4.8 44.6 1.0

N.T.Ross, F.Lohmann, S.Carbonneau, A.Fazal, W.A.Weihofen. CPSF3-Dependent Pre-Mrna Processing As A Druggable Node in Translocation Driven Aml and Ewing'S Sarcoma To Be Published.