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Chlorine in PDB 6mvo: Hcv NS5B 1A Y316 Bound to Compound 49Enzymatic activity of Hcv NS5B 1A Y316 Bound to Compound 49
All present enzymatic activity of Hcv NS5B 1A Y316 Bound to Compound 49:
2.7.7.48; Protein crystallography data
The structure of Hcv NS5B 1A Y316 Bound to Compound 49, PDB code: 6mvo
was solved by
S.P.Williams,
K.Kahler,
D.J.Price,
A.J.Peat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6mvo:
The structure of Hcv NS5B 1A Y316 Bound to Compound 49 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Hcv NS5B 1A Y316 Bound to Compound 49
(pdb code 6mvo). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Hcv NS5B 1A Y316 Bound to Compound 49, PDB code: 6mvo: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6mvoGo back to Chlorine Binding Sites List in 6mvo
Chlorine binding site 1 out
of 2 in the Hcv NS5B 1A Y316 Bound to Compound 49
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6mvoGo back to Chlorine Binding Sites List in 6mvo
Chlorine binding site 2 out
of 2 in the Hcv NS5B 1A Y316 Bound to Compound 49
Mono view Stereo pair view
Reference:
P.Y.Chong,
J.B.Shotwell,
J.Miller,
D.J.Price,
A.Maynard,
C.Voitenleitner,
A.Mathis,
S.Williams,
J.J.Pouliot,
K.Creech,
F.Wang,
J.Fang,
H.Zhang,
V.W.Tai,
E.Turner,
K.M.Kahler,
R.Crosby,
A.J.Peat.
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired By Metabolites of A Failed Clinical Hcv Inhibitor. J.Med.Chem. V. 62 3254 2019.
Page generated: Sat Dec 12 13:22:21 2020
ISSN: ISSN 0022-2623 PubMed: 30763090 DOI: 10.1021/ACS.JMEDCHEM.8B01719 |
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