Chlorine in PDB 6n3d: Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State)

The structure of Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State), PDB code: 6n3d was solved by S.Loerch, J.L.Jenkins, C.L.Kielkopf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.20 / 1.13
Space group	P 43
Cell size a, b, c (Å), α, β, γ (°)	30.201, 30.201, 98.742, 90.00, 90.00, 90.00
R / Rfree (%)	12.7 / 16

The structure of Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State) also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Chlorine atom in the Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State) (pdb code 6n3d). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State), PDB code: 6n3d:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl401 b:16.1 occ:0.89 HH12 A:ARG340 2.4 14.4 1.0 HH22 A:ARG340 2.5 16.1 1.0 NH1 A:ARG340 3.2 12.0 1.0 NH2 A:ARG340 3.2 13.4 1.0 HB2 A:HIS273 3.3 15.3 1.0 CZ A:ARG340 3.7 11.7 1.0 HH11 A:ARG340 3.9 14.4 1.0 HD2 A:HIS273 3.9 16.0 1.0 HH21 A:ARG340 4.0 16.1 1.0 CB A:HIS273 4.1 12.7 1.0 CD2 A:HIS273 4.3 13.3 1.0 HB3 A:HIS273 4.3 15.3 1.0 CG A:HIS273 4.4 12.2 1.0 NE A:ARG340 5.0 12.5 1.0

Chlorine binding site 2 out of 4 in the Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl402 b:19.0 occ:0.83 H A:LEU306 2.3 12.8 0.5 H A:LEU306 2.3 11.4 0.5 HE A:ARG288 2.4 21.9 1.0 HH21 A:ARG288 2.6 22.4 1.0 O A:HOH525 2.8 36.4 1.0 HA A:LEU305 3.0 13.4 1.0 N A:LEU306 3.1 10.7 0.5 N A:LEU306 3.2 9.5 0.5 O A:HOH549 3.2 20.2 1.0 NE A:ARG288 3.2 18.2 1.0 HB2 A:LEU306 3.3 15.7 0.5 NH2 A:ARG288 3.3 18.6 1.0 HB2 A:LEU306 3.5 12.2 0.5 HG A:LEU306 3.6 15.2 0.5 CZ A:ARG288 3.7 17.6 1.0 O A:LEU306 3.8 11.0 0.5 HD23 A:LEU305 3.8 23.0 1.0 O A:LEU306 3.8 10.1 0.5 CA A:LEU305 3.8 11.2 1.0 HD22 A:LEU305 3.9 23.0 1.0 C A:LEU305 4.0 10.5 1.0 CA A:LEU306 4.0 9.8 0.5 HH22 A:ARG288 4.0 22.4 1.0 CA A:LEU306 4.0 10.0 0.5 CB A:LEU306 4.1 10.1 0.5 CB A:LEU306 4.1 13.0 0.5 HD13 A:LEU306 4.1 16.5 0.5 CD2 A:LEU305 4.3 19.1 1.0 CG A:LEU306 4.3 12.7 0.5 HB3 A:LEU305 4.3 17.4 1.0 HD3 A:ARG288 4.3 19.3 1.0 O A:HOH591 4.4 30.8 1.0 C A:LEU306 4.4 8.5 0.5 CD A:ARG288 4.4 16.1 1.0 C A:LEU306 4.4 10.0 0.5 O A:LEU304 4.5 11.8 1.0 HG3 A:ARG288 4.5 18.0 1.0 O A:HOH582 4.6 47.6 1.0 HD12 A:LEU306 4.6 17.0 0.5 CB A:LEU305 4.6 14.5 1.0 HD12 A:LEU306 4.6 16.5 0.5 HB3 A:LEU306 4.7 15.7 0.5 CD1 A:LEU306 4.7 13.7 0.5 HD23 A:LEU304 4.8 21.0 1.0 O A:HOH544 4.9 42.9 1.0 N A:LEU305 4.9 9.3 1.0 HA A:LEU306 4.9 11.8 0.5 HA A:LEU306 4.9 12.0 0.5 HB3 A:LEU306 5.0 12.2 0.5 CG A:ARG288 5.0 15.0 1.0

Chlorine binding site 3 out of 4 in the Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:22.2 occ:0.75 HZ2 A:LYS297 2.2 30.8 1.0 HH22 A:ARG335 2.4 56.2 1.0 NZ A:LYS297 3.1 25.7 1.0 HH12 A:ARG335 3.2 53.0 1.0 NH2 A:ARG335 3.2 46.8 1.0 HD3 A:LYS297 3.3 27.3 1.0 HZ3 A:LYS297 3.5 30.8 1.0 HZ1 A:LYS297 3.6 30.8 1.0 HH21 A:ARG335 3.8 56.2 1.0 HE2 A:LYS297 3.8 30.5 1.0 NH1 A:ARG335 3.8 44.2 1.0 CE A:LYS297 3.8 25.4 1.0 CZ A:ARG335 4.0 41.0 1.0 CD A:LYS297 4.0 22.8 1.0 HD2 A:LYS297 4.3 27.3 1.0 HH11 A:ARG335 4.6 53.0 1.0 HE3 A:LYS297 4.8 30.5 1.0 OE2 A:GLU294 5.0 20.6 0.5 O A:HOH586 5.0 32.6 1.0

Chlorine binding site 4 out of 4 in the Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of Hiv Tat-Specific Factor 1 U2AF Homology Motif (Apo-State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl407 b:15.7 occ:0.37 HH21 A:ARG292 2.1 23.0 1.0 HE A:ARG292 2.2 17.9 1.0 HB3 A:LEU304 2.5 15.2 1.0 O A:LEU304 2.8 11.8 1.0 NH2 A:ARG292 2.9 19.1 1.0 NE A:ARG292 3.0 14.9 1.0 H A:LEU304 3.2 10.6 1.0 O A:HOH525 3.3 36.4 1.0 CZ A:ARG292 3.3 16.9 1.0 HD22 A:LEU304 3.4 21.0 1.0 CB A:LEU304 3.4 12.7 1.0 HH22 A:ARG292 3.6 23.0 1.0 C A:LEU304 3.7 10.0 1.0 HD23 A:LEU304 3.7 21.0 1.0 N A:LEU304 3.8 8.8 1.0 HD3 A:ARG288 3.8 19.3 1.0 CA A:LEU304 3.8 9.8 1.0 CD2 A:LEU304 3.9 17.5 1.0 HB2 A:LEU304 4.0 15.2 1.0 HG2 A:ARG292 4.1 18.6 1.0 O A:HOH591 4.2 30.8 1.0 CD A:ARG292 4.2 16.4 1.0 CG A:LEU304 4.3 15.5 1.0 HG3 A:ARG292 4.3 18.6 1.0 HG3 A:ARG288 4.4 18.0 1.0 CG A:ARG292 4.4 15.5 1.0 HG2 A:ARG288 4.5 18.0 1.0 CD A:ARG288 4.6 16.1 1.0 HD3 A:ARG292 4.6 19.7 1.0 NH1 A:ARG292 4.7 20.6 1.0 CG A:ARG288 4.7 15.0 1.0 HA A:LEU304 4.8 11.8 1.0 HD13 A:LEU304 4.8 21.9 1.0 HD21 A:LEU304 4.8 21.0 1.0 HA A:LYS303 4.9 11.7 1.0 HD2 A:ARG292 4.9 19.7 1.0 N A:LEU305 4.9 9.3 1.0 C A:LYS303 4.9 10.2 1.0 HA A:LEU305 5.0 13.4 1.0

S.Loerch, J.R.Leach, S.W.Horner, D.Maji, J.L.Jenkins, M.J.Pulvino, C.L.Kielkopf. The Pre-Mrna Splicing and Transcription Factor Tat-SF1 Is A Functional Partner of the Spliceosome SF3B1 Subunit Via A U2AF Homology Motif Interface. J. Biol. Chem. V. 294 2892 2019.
ISSN: ESSN 1083-351X
PubMed: 30567737
DOI: 10.1074/JBC.RA118.006764