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Chlorine in PDB 6n79: Structure of the Human JAK1 Kinase Domain with Compound 20Enzymatic activity of Structure of the Human JAK1 Kinase Domain with Compound 20
All present enzymatic activity of Structure of the Human JAK1 Kinase Domain with Compound 20:
2.7.10.2; Protein crystallography data
The structure of Structure of the Human JAK1 Kinase Domain with Compound 20, PDB code: 6n79
was solved by
P.J.Lupardus,
D.Brown,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6n79:
The structure of Structure of the Human JAK1 Kinase Domain with Compound 20 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of the Human JAK1 Kinase Domain with Compound 20
(pdb code 6n79). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of the Human JAK1 Kinase Domain with Compound 20, PDB code: 6n79: Chlorine binding site 1 out of 1 in 6n79Go back to Chlorine Binding Sites List in 6n79
Chlorine binding site 1 out
of 1 in the Structure of the Human JAK1 Kinase Domain with Compound 20
Mono view Stereo pair view
Reference:
M.Zak,
E.J.Hanan,
P.Lupardus,
D.G.Brown,
C.Robinson,
M.Siu,
J.P.Lyssikatos,
F.A.Romero,
G.Zhao,
T.Kellar,
R.Mendonca,
N.C.Ray,
S.C.Goodacre,
P.H.Crackett,
N.Mclean,
C.A.Hurley,
P.W.Yuen,
Y.X.Cheng,
X.Liu,
M.Liimatta,
P.B.Kohli,
J.Nonomiya,
G.Salmon,
G.Buckley,
J.Lloyd,
P.Gibbons,
N.Ghilardi,
J.R.Kenny,
A.Johnson.
Discovery of A Class of Highly Potent Janus Kinase 1/2 (JAK1/2) Inhibitors Demonstrating Effective Cell-Based Blockade of Il-13 Signaling. Bioorg.Med.Chem.Lett. V. 29 1522 2019.
Page generated: Sat Dec 12 13:22:47 2020
ISSN: ESSN 1464-3405 PubMed: 30981576 DOI: 10.1016/J.BMCL.2019.04.008 |
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