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Chlorine in PDB 6n82: Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037Enzymatic activity of Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037
All present enzymatic activity of Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037:
2.5.1.1; 2.5.1.10; Protein crystallography data
The structure of Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037, PDB code: 6n82
was solved by
J.Park,
M.A.Schilling,
A.M.Berghuis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6n82:
The structure of Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037
(pdb code 6n82). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037, PDB code: 6n82: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 6n82Go back to Chlorine Binding Sites List in 6n82
Chlorine binding site 1 out
of 4 in the Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037
Mono view Stereo pair view
Chlorine binding site 2 out of 4 in 6n82Go back to Chlorine Binding Sites List in 6n82
Chlorine binding site 2 out
of 4 in the Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037
Mono view Stereo pair view
Chlorine binding site 3 out of 4 in 6n82Go back to Chlorine Binding Sites List in 6n82
Chlorine binding site 3 out
of 4 in the Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037
Mono view Stereo pair view
Chlorine binding site 4 out of 4 in 6n82Go back to Chlorine Binding Sites List in 6n82
Chlorine binding site 4 out
of 4 in the Crystal Structure of Human Fpps in Complex with An Allosteric Inhibitor Yf-02037
Mono view Stereo pair view
Reference:
Y.Feng,
J.Park,
S.G.Li,
R.Boutin,
P.Viereck,
M.A.Schilling,
A.M.Berghuis,
Y.S.Tsantrizos.
Chirality-Driven Mode of Binding of Alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (Hfpps). J.Med.Chem. V. 62 9691 2019.
Page generated: Sat Dec 12 13:22:56 2020
ISSN: ISSN 0022-2623 PubMed: 31577901 DOI: 10.1021/ACS.JMEDCHEM.9B01104 |
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