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Chlorine in PDB 6ne5: Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Protein crystallography data
The structure of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer, PDB code: 6ne5
was solved by
B.Zhao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.61 / 1.85 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 39.332, 135.942, 60.051, 90.00, 95.95, 90.00 |
| R / Rfree (%) | 17.2 / 20.7 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
(pdb code 6ne5). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer, PDB code: 6ne5:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Chlorine where determined in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer, PDB code: 6ne5:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Chlorine binding site 1 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 1 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 2 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 2 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 3 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 3 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 4 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 4 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 5 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 5 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 6 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 6 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 7 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 7 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Chlorine binding site 8 out of 8 in 6ne5
Go back to
Chlorine Binding Sites List in 6ne5
Chlorine binding site 8 out
of 8 in the Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer within 5.0Å range:
|
Reference:
T.Lee,
P.P.Christov,
S.Shaw,
J.C.Tarr,
B.Zhao,
N.Veerasamy,
K.O.Jeon,
J.J.Mills,
Z.Bian,
J.L.Sensintaffar,
A.L.Arnold,
S.A.Fogarty,
E.Perry,
H.E.Ramsey,
R.S.Cook,
M.Hollingshead,
M.Davis Millin,
K.M.Lee,
B.Koss,
A.Budhraja,
J.T.Opferman,
K.Kim,
C.L.Arteaga,
W.J.Moore,
E.T.Olejniczak,
M.R.Savona,
S.W.Fesik.
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J.Med.Chem. V. 62 3971 2019.
ISSN: ISSN 0022-2623
PubMed: 30929420
DOI: 10.1021/ACS.JMEDCHEM.8B01991
Page generated: Mon Jul 29 11:55:37 2024
ISSN: ISSN 0022-2623
PubMed: 30929420
DOI: 10.1021/ACS.JMEDCHEM.8B01991
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