Chlorine in PDB 6nph: Structure of NKCC1 Tm Domain

The structure of Structure of NKCC1 Tm Domain also contains other interesting chemical elements:

Potassium

(K)

2 atoms

The binding sites of Chlorine atom in the Structure of NKCC1 Tm Domain (pdb code 6nph). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of NKCC1 Tm Domain, PDB code: 6nph:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structure of NKCC1 Tm Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of NKCC1 Tm Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl705 b:53.1 occ:1.00 N A:VAL224 3.0 51.4 1.0 CA A:GLY223 3.5 49.9 1.0 K A:K704 3.5 46.8 1.0 O A:PRO417 3.5 44.9 1.0 CA A:ALA418 3.6 45.4 1.0 N A:MET225 3.6 50.7 1.0 C A:GLY223 3.6 49.9 1.0 N A:GLY223 3.7 49.9 1.0 CE1 A:TYR305 3.8 51.0 1.0 N A:ALA418 3.9 45.4 1.0 C A:PRO417 4.0 44.9 1.0 CG A:MET225 4.0 50.7 1.0 CA A:VAL224 4.0 51.4 1.0 CB A:ALA418 4.1 45.4 1.0 O A:ILE221 4.1 47.4 1.0 C A:VAL224 4.3 51.4 1.0 CB A:VAL224 4.3 51.4 1.0 CB A:MET225 4.4 50.7 1.0 OH A:TYR305 4.4 51.0 1.0 CA A:MET225 4.6 50.7 1.0 CZ A:TYR305 4.6 51.0 1.0 O A:GLY223 4.6 49.9 1.0 CD1 A:TYR305 4.7 51.0 1.0 C A:ALA418 4.7 45.4 1.0 CE A:MET304 4.8 50.0 1.0 CG2 A:VAL224 4.8 51.4 1.0 C A:TRP222 4.9 49.0 1.0 O A:ALA418 5.0 45.4 1.0 CB A:PRO417 5.0 44.9 1.0 OH A:TYR454 5.0 45.3 1.0

Chlorine binding site 2 out of 4 in the Structure of NKCC1 Tm Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of NKCC1 Tm Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl706 b:55.7 occ:1.00 OH A:TYR611 3.0 43.2 1.0 N A:GLY421 3.4 47.9 1.0 CE1 A:PHE607 3.4 43.9 1.0 CE1 A:PHE294 3.5 48.9 1.0 CA A:GLY421 3.5 47.9 1.0 N A:LEU423 3.7 53.4 1.0 N A:ILE422 3.7 49.3 1.0 C A:GLY421 3.8 47.9 1.0 CB A:LEU423 3.9 53.4 1.0 CZ A:PHE294 4.0 48.9 1.0 CZ A:TYR611 4.0 43.2 1.0 CD1 A:PHE607 4.0 43.9 1.0 CG A:LEU423 4.1 53.4 1.0 CE1 A:TYR611 4.1 43.2 1.0 CZ A:PHE607 4.3 43.9 1.0 CA A:LEU423 4.3 53.4 1.0 C A:THR420 4.6 45.7 1.0 O A:GLY421 4.6 47.9 1.0 C A:ILE422 4.6 49.3 1.0 CD1 A:PHE294 4.7 48.9 1.0 CA A:ILE422 4.7 49.3 1.0 CD1 A:LEU423 4.7 53.4 1.0 CG1 A:ILE422 4.8 49.3 1.0 C A:LEU423 4.9 53.4 1.0 CB A:THR420 4.9 45.7 1.0

Chlorine binding site 3 out of 4 in the Structure of NKCC1 Tm Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of NKCC1 Tm Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl806 b:52.6 occ:1.00 N B:VAL224 3.0 51.9 1.0 CA B:GLY223 3.4 50.5 1.0 K B:K805 3.5 46.4 1.0 O B:PRO417 3.5 45.2 1.0 C B:GLY223 3.6 50.5 1.0 N B:MET225 3.6 51.1 1.0 CA B:ALA418 3.6 46.0 1.0 N B:GLY223 3.8 50.5 1.0 CE1 B:TYR305 3.8 51.4 1.0 N B:ALA418 4.0 46.0 1.0 C B:PRO417 4.0 45.2 1.0 CA B:VAL224 4.0 51.9 1.0 CG B:MET225 4.0 51.1 1.0 CB B:ALA418 4.1 46.0 1.0 O B:ILE221 4.1 47.4 1.0 CB B:VAL224 4.3 51.9 1.0 C B:VAL224 4.3 51.9 1.0 CB B:MET225 4.4 51.1 1.0 OH B:TYR305 4.4 51.4 1.0 CA B:MET225 4.6 51.1 1.0 CZ B:TYR305 4.6 51.4 1.0 O B:GLY223 4.6 50.5 1.0 CD1 B:TYR305 4.6 51.4 1.0 C B:ALA418 4.7 46.0 1.0 CE B:MET304 4.8 50.4 1.0 CG2 B:VAL224 4.8 51.9 1.0 C B:TRP222 4.9 49.2 1.0 CB B:PRO417 5.0 45.2 1.0 O B:ALA418 5.0 46.0 1.0

Chlorine binding site 4 out of 4 in the Structure of NKCC1 Tm Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of NKCC1 Tm Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl807 b:53.6 occ:1.00 OH B:TYR611 2.9 43.0 1.0 N B:GLY421 3.3 47.5 1.0 CE1 B:PHE607 3.4 43.4 1.0 CA B:GLY421 3.5 47.5 1.0 CE1 B:PHE294 3.6 48.5 1.0 N B:ILE422 3.6 49.2 1.0 N B:LEU423 3.7 53.2 1.0 C B:GLY421 3.8 47.5 1.0 CZ B:TYR611 3.9 43.0 1.0 CB B:LEU423 3.9 53.2 1.0 CD1 B:PHE607 4.0 43.4 1.0 CZ B:PHE294 4.0 48.5 1.0 CE1 B:TYR611 4.0 43.0 1.0 CG B:LEU423 4.1 53.2 1.0 CZ B:PHE607 4.3 43.4 1.0 CA B:LEU423 4.3 53.2 1.0 C B:THR420 4.6 45.8 1.0 C B:ILE422 4.6 49.2 1.0 O B:GLY421 4.7 47.5 1.0 CA B:ILE422 4.7 49.2 1.0 CD1 B:PHE294 4.7 48.5 1.0 CD1 B:LEU423 4.7 53.2 1.0 CG1 B:ILE422 4.7 49.2 1.0 CB B:THR420 4.9 45.8 1.0 C B:LEU423 5.0 53.2 1.0 CA B:THR420 5.0 45.8 1.0

T.A.Chew, B.J.Orlando, J.Zhang, N.R.Latorraca, A.Wang, S.A.Hollingsworth, D.H.Chen, R.O.Dror, M.Liao, L.Feng. Structure and Mechanism of the Cation-Chloride Cotransporter NKCC1. Nature V. 572 488 2019.
ISSN: ESSN 1476-4687
PubMed: 31367042
DOI: 10.1038/S41586-019-1438-2