Chlorine in PDB 6nwv: Insulin Lispro Analog

The structure of Insulin Lispro Analog, PDB code: 6nwv was solved by A.Cruz-Rangel, A.Romero, J.P.Reyes-Grajeda, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.96 / 1.60
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	46.161, 61.789, 58.618, 90.00, 111.46, 90.00
R / Rfree (%)	20.8 / 25.7

The structure of Insulin Lispro Analog also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Insulin Lispro Analog (pdb code 6nwv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Insulin Lispro Analog, PDB code: 6nwv:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Insulin Lispro Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Insulin Lispro Analog within 5.0Å range: probe atom residue distance (Å) B Occ J:Cl101 b:46.7 occ:1.00 ZN F:ZN101 2.5 21.9 1.0 NE2 J:HIS10 3.5 22.9 1.0 NE2 F:HIS10 3.5 21.8 1.0 NE2 H:HIS10 3.5 22.5 1.0 CD2 J:HIS10 3.8 22.1 1.0 O H:HOH110 3.9 24.3 1.0 CB F:LEU6 3.9 24.2 1.0 CD2 H:HIS10 4.0 20.8 1.0 CB J:LEU6 4.0 27.0 1.0 CD1 F:LEU6 4.0 28.4 1.0 CD2 F:HIS10 4.1 22.3 1.0 CG F:LEU6 4.3 29.8 1.0 CB H:LEU6 4.4 21.5 1.0 CD2 F:LEU6 4.5 28.2 1.0 CD1 J:LEU6 4.5 26.2 1.0 CE1 F:HIS10 4.7 23.9 1.0 CE1 J:HIS10 4.7 22.8 1.0 CE1 H:HIS10 4.7 26.8 1.0 CD1 H:LEU6 4.8 30.0 1.0 C J:LEU6 4.8 25.9 1.0 CG J:LEU6 4.9 31.2 1.0 O J:LEU6 4.9 25.6 1.0 CA F:LEU6 4.9 22.6 1.0

Chlorine binding site 2 out of 2 in the Insulin Lispro Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Insulin Lispro Analog within 5.0Å range: probe atom residue distance (Å) B Occ L:Cl101 b:43.6 occ:1.00 ZN B:ZN101 2.4 21.7 1.0 NE2 L:HIS10 3.4 20.9 1.0 NE2 D:HIS10 3.6 23.1 1.0 NE2 B:HIS10 3.6 19.5 1.0 CD1 D:LEU6 3.8 28.3 1.0 CD2 L:HIS10 3.8 22.4 1.0 CB B:LEU6 3.9 26.5 1.0 O L:HOH210 3.9 28.2 1.0 CD2 B:HIS10 4.0 20.8 1.0 CD1 B:LEU6 4.1 29.6 1.0 CB D:LEU6 4.1 23.3 1.0 CD2 D:HIS10 4.1 21.8 1.0 CB L:LEU6 4.3 22.0 1.0 C1 D:GOL101 4.3 51.5 1.0 O1 D:GOL101 4.5 42.7 1.0 O B:HOH206 4.5 51.7 1.0 CG D:LEU6 4.5 24.9 1.0 CG B:LEU6 4.6 29.0 1.0 CE1 L:HIS10 4.6 24.4 1.0 CD1 L:LEU6 4.7 27.8 1.0 CE1 D:HIS10 4.8 22.0 1.0 CE1 B:HIS10 4.8 25.0 1.0 O B:LEU6 4.9 24.6 1.0 C B:LEU6 4.9 24.7 1.0 CA B:LEU6 5.0 25.8 1.0

A.Cruz-Rangel, A.Romero, J.P.Reyes-Grajeda. Crystal Structure of Lispro Hexameric Insulin Analog To Be Published.