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Chlorine in PDB 6o2z: Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32Enzymatic activity of Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32
All present enzymatic activity of Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32:
1.1.1.42; Protein crystallography data
The structure of Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32, PDB code: 6o2z
was solved by
A.V.Toms,
J.Lin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32
(pdb code 6o2z). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32, PDB code: 6o2z: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6o2zGo back to Chlorine Binding Sites List in 6o2z
Chlorine binding site 1 out
of 2 in the Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6o2zGo back to Chlorine Binding Sites List in 6o2z
Chlorine binding site 2 out
of 2 in the Crystal Structure of IDH1 R132H Mutant in Complex with Compound 32
Mono view Stereo pair view
Reference:
J.Lin,
W.Lu,
J.A.Caravella,
A.M.Campbell,
R.B.Diebold,
A.Ericsson,
E.Fritzen,
G.R.Gustafson,
D.R.Lancia Jr.,
T.Shelekhin,
Z.Wang,
J.Castro,
A.Clarke,
D.Gotur,
H.R.Josephine,
M.Katz,
H.Diep,
M.Kershaw,
L.Yao,
G.Kauffman,
S.E.Hubbs,
G.P.Luke,
A.V.Toms,
L.Wang,
K.W.Bair,
K.J.Barr,
C.Dinsmore,
D.Walker,
S.Ashwell.
Discovery and Optimization of Quinolinone Derivatives As Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (MIDH1) Inhibitors. J.Med.Chem. V. 62 6575 2019.
Page generated: Sat Dec 12 13:25:46 2020
ISSN: ISSN 0022-2623 PubMed: 31199148 DOI: 10.1021/ACS.JMEDCHEM.9B00362 |
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