Chlorine in PDB 6od5: Human TCF4 C-Terminal Bhlh Domain in Complex with 12-Bp Oligonucleotide Containing E-Box Sequence with 5-Carboxylcytosines

The structure of Human TCF4 C-Terminal Bhlh Domain in Complex with 12-Bp Oligonucleotide Containing E-Box Sequence with 5-Carboxylcytosines, PDB code: 6od5 was solved by J.R.Horton, X.Cheng, J.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.66 / 2.05
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	44.677, 44.757, 54.640, 78.63, 78.88, 79.27
R / Rfree (%)	23.4 / 28

The binding sites of Chlorine atom in the Human TCF4 C-Terminal Bhlh Domain in Complex with 12-Bp Oligonucleotide Containing E-Box Sequence with 5-Carboxylcytosines (pdb code 6od5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human TCF4 C-Terminal Bhlh Domain in Complex with 12-Bp Oligonucleotide Containing E-Box Sequence with 5-Carboxylcytosines, PDB code: 6od5:

Chlorine binding site 1 out of 1 in the Human TCF4 C-Terminal Bhlh Domain in Complex with 12-Bp Oligonucleotide Containing E-Box Sequence with 5-Carboxylcytosines


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human TCF4 C-Terminal Bhlh Domain in Complex with 12-Bp Oligonucleotide Containing E-Box Sequence with 5-Carboxylcytosines within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl702 b:56.6 occ:1.00 O A:HOH815 3.3 33.4 1.0 NH1 A:ARG570 3.5 37.6 1.0 CD A:ARG570 3.5 33.5 1.0 N A:HIS567 3.7 43.7 1.0 CA A:HIS567 3.8 42.7 1.0 CB A:HIS567 4.4 46.4 1.0 NE A:ARG570 4.5 34.0 1.0 CZ A:ARG570 4.5 36.2 1.0 CG A:ARG570 4.6 30.6 1.0 C A:HIS567 5.0 40.6 1.0 O A:HOH812 5.0 32.0 1.0

J.Yang, J.R.Horton, J.Li, Y.Huang, X.Zhang, R.M.Blumenthal, X.Cheng. Structural Basis For Preferential Binding of Human TCF4 to Dna Containing 5-Carboxylcytosine. Nucleic Acids Res. V. 47 8375 2019.
ISSN: ESSN 1362-4962
PubMed: 31081034
DOI: 10.1093/NAR/GKZ381