Chlorine in PDB 6ogn: Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe

Enzymatic activity of Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe

All present enzymatic activity of Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe:
2.1.1.321;

Protein crystallography data

The structure of Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe, PDB code: 6ogn was solved by L.Halabelian, A.Dong, H.Zeng, Y.Li, A.Hutchinson, A.Seitova, C.Bountra, A.M.Edwards, C.H.Arrowsmith, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	47.03 / 2.40
*Space group*	P 4₃ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	97.813, 97.813, 169.539, 90.00, 90.00, 90.00
*R / R_free (%)*	20.8 / 26.1

Other elements in 6ogn:

The structure of Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe (pdb code 6ogn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe, PDB code: 6ogn:

Chlorine binding site 1 out of 1 in 6ogn

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Chlorine Binding Sites List in 6ogn

Chlorine binding site 1 out of 1 in the Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl702 b:92.8 occ:1.00	CL	A:MJ7702	0.0	92.8	1.0
	C23	A:MJ7702	1.8	79.5	1.0
	C24	A:MJ7702	2.7	70.7	1.0
	C22	A:MJ7702	2.7	65.1	1.0
	CE	A:MET286	3.2	63.9	1.0
	CG1	A:ILE284	3.5	62.5	1.0
	SG	A:CYS294	3.6	79.6	1.0
	CE2	A:TYR48	3.7	54.9	1.0
	C25	A:MJ7702	4.0	75.5	1.0
	C21	A:MJ7702	4.0	65.1	1.0
	CG	A:ARG44	4.1	73.7	1.0
	CB	A:CYS294	4.3	59.7	1.0
	CD2	A:TYR48	4.3	49.4	1.0
	CZ	A:TYR48	4.4	45.8	1.0
	CB	A:ILE284	4.4	57.8	1.0
	OH	A:TYR48	4.5	51.1	1.0
	C20	A:MJ7702	4.5	69.7	1.0
	SD	A:MET286	4.7	61.2	1.0
	CB	A:ARG44	4.8	60.9	1.0
	CG2	A:ILE284	4.8	60.5	1.0
	CA	A:ARG44	4.8	56.8	1.0
	CD	A:ARG44	5.0	85.0	1.0

Reference:

L.Halabelian, A.Dong, H.Zeng, Y.Li, A.Hutchinson, A.Seitova, C.Bountra, A.M.Edwards, C.H.Arrowsmith. Crystal Structure of Mouse Protein Arginine Methyltransferase 7 in Complex with SGC8158 Chemical Probe To Be Published.

Page generated: Mon Jul 29 12:40:45 2024

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