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Chlorine in PDB 6oi8: Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-AmineEnzymatic activity of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-Amine
All present enzymatic activity of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-Amine:
6.3.4.14; 6.4.1.2; Protein crystallography data
The structure of Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-Amine, PDB code: 6oi8
was solved by
L.D.Andrews,
T.R.Kane,
P.Dozzo,
C.M.Haglund,
D.J.Hilderbrandt,
M.S.Linsell,
T.Machajewski,
G.Mcenroe,
A.W.Serio,
K.B.Wlasichuk,
D.B.Neau,
S.Pakhomova,
G.L.Waldrop,
M.Sharp,
J.Pogliano,
R.Cirz,
F.Cohen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-Amine
(pdb code 6oi8). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-Amine, PDB code: 6oi8: Chlorine binding site 1 out of 1 in 6oi8Go back to Chlorine Binding Sites List in 6oi8
Chlorine binding site 1 out
of 1 in the Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6S)-6-Amino-3-Azabicyclo[3.1.0]Hexan-3-Yl)- 6-(2-Chloro-6-(Pyridin-3-Yl)Phenyl)Pyrido[2,3-D]Pyrimidin-2-Amine
Mono view Stereo pair view
Reference:
L.D.Andrews,
T.R.Kane,
P.Dozzo,
C.M.Haglund,
D.J.Hilderbrandt,
M.S.Linsell,
T.Machajewski,
G.Mcenroe,
A.W.Serio,
K.B.Wlasichuk,
D.B.Neau,
S.Pakhomova,
G.L.Waldrop,
M.Sharp,
J.Pogliano,
R.T.Cirz,
F.Cohen.
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. J.Med.Chem. V. 62 7489 2019.
Page generated: Sat Dec 12 13:27:02 2020
ISSN: ISSN 0022-2623 PubMed: 31306011 DOI: 10.1021/ACS.JMEDCHEM.9B00625 |
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