Chlorine in PDB 6owv: Crystal Structure of A Human Cardiac Calsequestrin Filament

The structure of Crystal Structure of A Human Cardiac Calsequestrin Filament, PDB code: 6owv was solved by E.W.Titus, F.H.Deiter, C.Shi, N.Jura, R.C.Deo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	53.94 / 1.88
Space group	P 43 2 2
Cell size a, b, c (Å), α, β, γ (°)	62.533, 62.533, 213.189, 90.00, 90.00, 90.00
R / Rfree (%)	21.3 / 24.9

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 25;

Binding sites:

The binding sites of Chlorine atom in the Crystal Structure of A Human Cardiac Calsequestrin Filament (pdb code 6owv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 25 binding sites of Chlorine where determined in the Crystal Structure of A Human Cardiac Calsequestrin Filament, PDB code: 6owv:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:81.9 occ:0.77 NZ A:LYS320 3.3 93.1 1.0 CD1 A:TYR317 3.4 71.5 1.0 CE A:LYS320 3.5 81.2 1.0 CE1 A:TYR317 3.5 79.8 1.0 CG A:TYR317 4.6 69.1 1.0 CZ A:TYR317 4.8 87.2 1.0 CD A:LYS320 5.0 87.2 1.0

Chlorine binding site 2 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:93.6 occ:1.00 CG A:LYS320 3.9 77.4 1.0 OE1 A:GLU319 4.1 65.8 1.0 CD A:LYS320 4.5 87.2 1.0 CB A:GLU319 4.5 55.0 1.0 N A:LYS320 4.8 65.1 1.0 C A:GLU319 4.9 73.2 1.0 CA A:LYS320 5.0 74.7 1.0 O A:ALA316 5.0 57.0 1.0

Chlorine binding site 3 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl405 b:84.9 occ:1.00 OG A:SER173 3.0 54.0 1.0 N A:SER176 3.7 51.8 1.0 CA A:SER176 3.8 51.6 1.0 CB A:SER176 3.8 58.4 1.0 CB A:SER173 3.9 53.4 1.0 CB A:LYS172 4.0 45.9 1.0 CG A:LYS172 4.0 51.5 1.0 CE A:LYS172 4.1 72.7 1.0 C A:ASP175 4.1 57.2 1.0 N A:SER173 4.2 45.0 1.0 CB A:ASP175 4.2 50.2 1.0 CA A:SER173 4.5 47.1 1.0 O A:ASP175 4.6 54.2 1.0 C A:LYS172 4.6 51.8 1.0 CA A:ASP175 4.6 49.6 1.0 CD A:LYS172 4.6 66.7 1.0 O A:SER173 4.7 45.5 1.0 N A:ASP175 4.8 50.3 1.0 C A:SER173 4.8 47.6 1.0 OG A:SER176 4.8 67.1 1.0 CA A:LYS172 4.9 47.8 1.0

Chlorine binding site 4 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl406 b:68.1 occ:0.50 N A:ILE270 2.9 57.9 1.0 O A:SER302 2.9 75.3 1.0 O A:ILE268 3.0 0.4 1.0 CL A:CL426 3.2 0.9 1.0 CA A:HIS269 3.4 72.4 1.0 C A:HIS269 3.6 76.4 1.0 C A:ILE268 3.8 0.3 1.0 CG1 A:ILE270 3.8 75.3 1.0 CB A:ILE270 3.9 60.6 1.0 N A:HIS269 3.9 93.2 1.0 CA A:ILE270 3.9 61.2 1.0 C A:SER302 4.0 68.9 1.0 CB A:SER302 4.4 84.0 1.0 O A:ILE270 4.4 58.7 1.0 CD1 A:ILE270 4.5 71.4 1.0 CA A:SER302 4.6 77.2 1.0 CB A:HIS269 4.6 91.4 1.0 N A:SER302 4.6 87.4 1.0 ND1 A:HIS269 4.7 1.0 1.0 C A:ILE270 4.7 67.2 1.0 O A:HIS269 4.8 67.2 1.0 CG A:HIS269 5.0 1.0 1.0

Chlorine binding site 5 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl407 b:0.3 occ:1.00 OE2 A:GLU184 3.0 95.9 1.0 OE1 A:GLU187 3.6 0.2 1.0 OE1 A:GLU184 3.8 94.8 1.0 CD A:GLU184 3.8 86.2 1.0 OE2 A:GLU187 4.3 87.5 1.0 CD A:GLU187 4.4 83.1 1.0 NZ A:LYS180 4.6 76.2 1.0 CL A:CL427 4.7 1.0 1.0 OD1 A:ASP120 4.8 0.7 1.0

Chlorine binding site 6 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl408 b:78.2 occ:0.80 OD2 A:ASP163 3.1 0.4 1.0 NZ A:LYS276 3.3 0.1 1.0 CE A:LYS276 3.6 80.9 1.0 OD1 A:ASP163 3.7 0.8 1.0 CE1 A:PHE220 3.8 78.6 1.0 CG A:ASP163 3.8 0.9 1.0 NZ A:LYS289 4.0 79.0 1.0 CD A:LYS276 4.0 61.6 1.0 CD2 A:LEU285 4.1 49.2 1.0 CH2 A:TRP305 4.2 59.6 1.0 CZ3 A:TRP305 4.2 58.5 1.0 CE A:LYS289 4.3 66.5 1.0 NH1 A:ARG251 4.4 85.7 1.0 CD1 A:PHE220 4.6 66.7 1.0 CZ A:PHE220 4.7 76.2 1.0 O3 A:SO4402 4.8 0.3 0.5

Chlorine binding site 7 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl409 b:84.4 occ:0.71 OE2 A:GLU319 3.0 70.7 1.0 OD1 A:ASP325 3.0 68.0 1.0 CG A:ASP325 3.4 71.2 1.0 OE1 A:GLU319 3.5 65.8 1.0 CD A:GLU319 3.6 65.2 1.0 OD2 A:ASP325 3.9 68.0 1.0 CB A:ASP325 3.9 52.3 1.0 CA A:ASP325 4.1 51.4 1.0 CD2 A:PHE327 4.5 58.8 1.0 CG A:GLU319 5.0 51.5 1.0

Chlorine binding site 8 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl410 b:66.8 occ:0.47 O A:HOH513 2.4 53.5 1.0 O A:PRO145 2.9 57.0 1.0 O A:ILE193 3.1 49.1 1.0 N A:PHE195 3.4 43.9 1.0 CA A:LYS194 3.5 49.4 1.0 CL A:CL425 3.6 0.0 1.0 C A:PRO145 3.9 61.8 1.0 CD A:LYS194 3.9 97.0 1.0 C A:LYS194 4.0 51.1 1.0 C A:ILE193 4.0 59.5 1.0 CA A:PRO145 4.1 70.9 1.0 N A:LYS194 4.3 47.4 1.0 CB A:LYS194 4.4 67.1 1.0 CA A:PHE195 4.5 48.2 1.0 CB A:PHE195 4.5 45.4 1.0 CD1 A:PHE195 4.5 50.9 1.0 CB A:PRO145 4.6 83.2 1.0 O A:PHE195 4.6 44.0 1.0 CG A:LYS194 4.8 87.0 1.0 CG A:GLN190 4.8 82.0 1.0 CG A:PHE195 5.0 48.5 1.0

Chlorine binding site 9 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl411 b:72.1 occ:0.59 O A:HOH526 2.9 52.8 1.0 CB A:ALA130 4.3 65.2 1.0 OE2 A:GLU128 4.7 85.7 1.0 CA A:ALA130 5.0 63.5 1.0

Chlorine binding site 10 out of 25 in the Crystal Structure of A Human Cardiac Calsequestrin Filament


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Crystal Structure of A Human Cardiac Calsequestrin Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl412 b:0.2 occ:1.00 OE1 A:GLU286 3.4 90.3 1.0 NZ A:LYS289 3.6 79.0 1.0 OE2 A:GLU286 4.0 97.9 1.0 CD A:GLU286 4.1 88.5 1.0 CD A:LYS289 4.1 53.9 1.0 CE A:LYS289 4.5 66.5 1.0

E.W.Titus, F.H.Deiter, C.Shi, J.Wojciak, M.Scheinman, N.Jura, R.C.Deo. The Structure of A Calsequestrin Filament Reveals Mechanisms of Familial Arrhythmia. Nat.Struct.Mol.Biol. 2020.
ISSN: ESSN 1545-9985
PubMed: 33046906
DOI: 10.1038/S41594-020-0510-9