Chlorine in PDB 6pbj: The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation

Enzymatic activity of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation

All present enzymatic activity of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation:
2.5.1.54;

Protein crystallography data

The structure of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation, PDB code: 6pbj was solved by W.Jiao, Y.Fan, N.J.Blackmore, E.J.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.83 / 1.90
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 204.251, 204.251, 66.551, 90.00, 90.00, 120.00
R / Rfree (%) 15.8 / 18

Other elements in 6pbj:

The structure of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation (pdb code 6pbj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation, PDB code: 6pbj:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 6pbj

Go back to Chlorine Binding Sites List in 6pbj
Chlorine binding site 1 out of 6 in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl506

b:54.4
occ:1.00
 CB A:HIS341 3.3 46.0 1.0
NH2 A:ARG386 3.3 53.9 1.0
N A:HIS341 3.4 41.9 1.0
CD2 A:HIS341 3.5 55.5 1.0
CA A:GLY339 3.7 27.8 1.0
CG A:HIS341 3.7 50.3 1.0
C A:GLY339 3.7 27.8 1.0
N A:ASN340 3.8 32.2 1.0
CA A:HIS341 3.8 40.8 1.0
CE A:LYS342 3.9 50.2 1.0
CG A:LYS342 4.2 43.2 1.0
OD1 A:ASN340 4.2 29.7 1.0
N A:LYS342 4.2 35.1 1.0
O A:GLY339 4.3 25.7 1.0
C A:HIS341 4.4 36.8 1.0
C A:ASN340 4.5 39.1 1.0
OD1 A:ASN371 4.5 40.8 1.0
O A:GLY370 4.5 44.0 1.0
CZ A:ARG386 4.5 60.8 1.0
CD A:LYS342 4.6 48.2 1.0
O A:MET338 4.7 32.8 1.0
CA A:ASN340 4.7 30.7 1.0
NE2 A:HIS341 4.8 57.5 1.0
CB A:LYS342 4.9 43.3 1.0
N A:GLY339 4.9 31.4 1.0

Chlorine binding site 2 out of 6 in 6pbj

Go back to Chlorine Binding Sites List in 6pbj
Chlorine binding site 2 out of 6 in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl507

b:61.4
occ:1.00
 NE2 A:HIS326 3.2 43.9 1.0
CE1 A:HIS326 3.9 43.4 1.0
NH2 A:ARG25 3.9 33.3 1.0
CD2 A:HIS326 4.3 39.3 1.0
CZ A:ARG25 4.7 36.5 1.0
O A:HOH729 4.8 31.2 1.0
NH1 A:ARG25 4.8 40.6 1.0

Chlorine binding site 3 out of 6 in 6pbj

Go back to Chlorine Binding Sites List in 6pbj
Chlorine binding site 3 out of 6 in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl508

b:38.6
occ:1.00
 NH1 A:ARG171 3.2 16.0 1.0
CG B:PRO8 3.7 33.7 1.0
NH2 A:ARG171 3.8 16.0 1.0
NH2 A:ARG168 3.9 17.4 1.0
O A:HOH795 3.9 27.0 1.0
O A:HOH693 3.9 19.1 1.0
O A:HOH646 4.0 13.4 1.0
CD B:PRO8 4.0 28.1 1.0
CZ A:ARG171 4.0 15.8 1.0
NH1 A:ARG168 4.4 13.3 1.0
CZ A:ARG168 4.6 14.9 1.0
O A:HOH824 5.0 41.2 1.0

Chlorine binding site 4 out of 6 in 6pbj

Go back to Chlorine Binding Sites List in 6pbj
Chlorine binding site 4 out of 6 in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl506

b:55.7
occ:1.00
 O B:HOH712 3.6 28.6 1.0
NH1 B:ARG49 3.6 18.1 1.0
NH1 B:ARG256 3.7 23.6 1.0
NH2 B:ARG256 3.9 20.6 1.0
CZ B:ARG256 4.3 20.6 1.0
CZ B:ARG49 4.5 17.5 1.0
NH2 B:ARG49 4.6 17.1 1.0

Chlorine binding site 5 out of 6 in 6pbj

Go back to Chlorine Binding Sites List in 6pbj
Chlorine binding site 5 out of 6 in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl507

b:58.8
occ:1.00
 NE2 B:HIS326 3.6 37.3 1.0
O B:HOH834 3.7 18.4 1.0
NH2 B:ARG25 3.8 18.8 1.0
NH1 B:ARG25 4.0 17.6 1.0
O B:HOH868 4.1 28.9 1.0
CZ B:ARG25 4.3 13.2 1.0
O B:HOH713 4.3 25.7 1.0
CD2 B:HIS326 4.5 37.9 1.0
CE1 B:HIS326 4.6 41.0 1.0

Chlorine binding site 6 out of 6 in 6pbj

Go back to Chlorine Binding Sites List in 6pbj
Chlorine binding site 6 out of 6 in the The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase with GLY190PRO Mutation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl508

b:49.7
occ:1.00
 O B:HOH855 3.2 47.5 1.0
NH2 B:ARG386 3.3 58.8 1.0
N B:HIS341 3.4 33.2 1.0
CB B:HIS341 3.4 44.3 1.0
ND1 B:HIS341 3.5 54.3 1.0
CA B:GLY339 3.6 23.8 1.0
C B:GLY339 3.7 23.8 1.0
N B:ASN340 3.7 27.2 1.0
CG B:HIS341 3.8 41.5 1.0
CA B:HIS341 3.9 33.7 1.0
CE B:LYS342 4.2 53.8 1.0
OD1 B:ASN340 4.2 22.6 1.0
O B:GLY339 4.3 21.9 1.0
OD1 B:ASN371 4.4 39.0 1.0
O B:GLY370 4.4 42.4 1.0
N B:LYS342 4.4 28.1 1.0
CG B:LYS342 4.4 35.0 1.0
NZ B:LYS342 4.4 60.0 1.0
C B:ASN340 4.5 24.9 1.0
C B:HIS341 4.5 30.8 1.0
CE1 B:HIS341 4.6 51.1 1.0
CZ B:ARG386 4.6 62.6 1.0
O B:MET338 4.6 20.6 1.0
CA B:ASN340 4.7 27.7 1.0
CD B:LYS342 4.8 46.5 1.0
N B:GLY339 4.9 21.4 1.0
CD2 B:HIS341 4.9 48.6 1.0

Reference:

W.Jiao, Y.Fan, N.J.Blackmore, E.J.Parker. Single Amino Acid Substitution Severs Dynamic Communication Pathway To Be Published.
Page generated: Sat Dec 12 13:29:29 2020

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