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Chlorine in PDB 6plf: Crystal Structure of Human Phgdh Complexed with Compound 1Enzymatic activity of Crystal Structure of Human Phgdh Complexed with Compound 1
All present enzymatic activity of Crystal Structure of Human Phgdh Complexed with Compound 1:
1.1.1.37; 1.1.1.399; 1.1.1.95; Protein crystallography data
The structure of Crystal Structure of Human Phgdh Complexed with Compound 1, PDB code: 6plf
was solved by
A.Olland,
D.Lakshminarasimhan,
A.White,
R.K.Suto,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Phgdh Complexed with Compound 1
(pdb code 6plf). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Phgdh Complexed with Compound 1, PDB code: 6plf: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 6plfGo back to Chlorine Binding Sites List in 6plf
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Phgdh Complexed with Compound 1
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 6plfGo back to Chlorine Binding Sites List in 6plf
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Phgdh Complexed with Compound 1
Mono view Stereo pair view
Reference:
E.Mullarky,
J.Xu,
A.D.Robin,
D.J.Huggins,
A.Jennings,
N.Noguchi,
A.Olland,
D.Lakshminarasimhan,
M.Miller,
D.Tomita,
M.Michino,
T.Su,
G.Zhang,
A.W.Stamford,
P.T.Meinke,
S.Kargman,
L.C.Cantley.
Inhibition of 3-Phosphoglycerate Dehydrogenase (Phgdh) By Indole Amides Abrogates De Novo Serine Synthesis in Cancer Cells. Bioorg.Med.Chem.Lett. V. 29 2503 2019.
Page generated: Sat Dec 12 13:30:46 2020
ISSN: ESSN 1464-3405 PubMed: 31327531 DOI: 10.1016/J.BMCL.2019.07.011 |
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