Chlorine in PDB 6pma: Trk-A in Complex with Ligand

All present enzymatic activity of Trk-A in Complex with Ligand:
2.7.10.1;

The structure of Trk-A in Complex with Ligand, PDB code: 6pma was solved by G.Subramanian, D.G.Brown, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.16 / 2.53
Space group	P 31 1 2
Cell size a, b, c (Å), α, β, γ (°)	52.094, 52.094, 227.160, 90.00, 90.00, 120.00
R / Rfree (%)	20.5 / 26.6

The structure of Trk-A in Complex with Ligand also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Chlorine atom in the Trk-A in Complex with Ligand (pdb code 6pma). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trk-A in Complex with Ligand, PDB code: 6pma:

Chlorine binding site 1 out of 1 in the Trk-A in Complex with Ligand


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trk-A in Complex with Ligand within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl801 b:72.3 occ:1.00 CL1 A:OQS801 0.0 72.3 1.0 C17 A:OQS801 1.7 45.1 1.0 C16 A:OQS801 2.7 43.7 1.0 C11 A:OQS801 2.7 42.7 1.0 N4 A:OQS801 3.0 42.7 1.0 OE1 A:GLU560 3.1 44.2 1.0 CD A:GLU560 3.5 45.4 1.0 CG A:GLU560 3.5 44.9 1.0 O A:ASP668 3.8 37.2 1.0 C15 A:OQS801 4.0 43.6 1.0 C12 A:OQS801 4.0 42.6 1.0 C10 A:OQS801 4.2 37.0 1.0 OE2 A:GLU560 4.3 43.8 1.0 C13 A:OQS801 4.5 41.7 1.0 CB A:ASP668 4.5 42.4 1.0 CB A:GLU560 4.8 43.3 1.0 C A:ASP668 4.9 38.0 1.0 C9 A:OQS801 4.9 34.1 1.0 O3 A:OQS801 5.0 38.8 1.0

G.Subramanian, S.J.Bowen, Y.Zhu, N.Roush, T.Zachary, C.Javens, T.Williams, A.Janssen, A.Gonzales. Synthetic Inhibitor Leads of Human Tropomyosin Receptor Kinase A (Htrka) Rsc Med Chem 2020.
DOI: 10.1039/C9MD00554D