Chlorine in PDB 6q2q: Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine

The structure of Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine, PDB code: 6q2q was solved by M.K.Fenwick, M.Dong, H.Lin, S.E.Ealick, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.30 / 1.89
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	36.455, 141.265, 143.488, 90.00, 90.00, 90.00
R / Rfree (%)	14.6 / 18.2

The structure of Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine also contains other interesting chemical elements:

Iron

(Fe)

8 atoms

The binding sites of Chlorine atom in the Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine (pdb code 6q2q). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine, PDB code: 6q2q:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:44.4 occ:1.00 O A:HOH790 2.9 48.7 1.0 N A:LYS198 3.0 31.3 1.0 O A:HOH544 3.3 22.3 1.0 N A:GLY197 3.4 28.4 1.0 N A:LYS199 3.4 19.0 1.0 N A:GLN196 3.4 29.2 1.0 CE1 A:HIS201 3.6 25.2 0.4 CB A:LYS198 3.7 32.2 1.0 CG A:GLN196 3.7 54.1 1.0 CA A:LYS198 3.8 29.7 1.0 NE2 A:HIS201 3.8 24.3 0.4 C A:GLY197 3.9 35.0 1.0 C A:GLN196 4.0 33.7 1.0 O A:HOH746 4.0 33.9 1.0 CA A:GLY197 4.1 37.0 1.0 C A:LYS198 4.1 23.7 1.0 CA A:GLN196 4.1 34.5 1.0 CB A:LYS199 4.3 31.8 1.0 C A:GLY195 4.3 24.2 1.0 CA A:GLY195 4.3 24.1 1.0 CA A:LYS199 4.4 28.4 1.0 CG A:LYS199 4.5 30.9 1.0 CB A:GLN196 4.5 43.3 1.0 ND1 A:HIS201 4.7 25.1 0.4 O A:GLN196 4.8 35.3 1.0 CD A:GLN196 4.9 62.8 1.0 O A:HOH533 4.9 63.5 1.0 NE2 A:GLN196 5.0 65.0 1.0 CG A:LYS198 5.0 32.8 1.0

Chlorine binding site 2 out of 4 in the Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl405 b:20.4 occ:1.00 NZ A:LYS114 3.1 10.3 1.0 O A:HOH641 3.1 7.8 1.0 CG A:LYS114 3.6 9.1 1.0 O A:HOH628 3.6 28.0 1.0 CE A:LYS114 3.8 14.8 1.0 CD A:LYS114 4.3 11.3 1.0 O A:LYS114 4.7 10.1 1.0 O A:LEU148 4.8 9.3 1.0 CB A:LYS114 4.9 8.3 1.0 O A:HOH580 5.0 27.2 1.0

Chlorine binding site 3 out of 4 in the Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl407 b:29.7 occ:1.00 NZ A:LYS297 3.0 38.7 1.0 N A:SER294 3.2 9.4 1.0 O A:PRO292 3.7 12.0 1.0 OG A:SER294 3.7 10.3 1.0 C A:PRO292 3.8 9.9 1.0 CB A:SER294 3.8 11.5 1.0 O A:HOH623 3.9 22.0 1.0 CD A:LYS297 3.9 28.7 1.0 N A:GLU293 3.9 8.7 1.0 CB A:PRO292 3.9 11.8 1.0 CA A:GLU293 3.9 7.1 1.0 CE A:LYS297 4.0 36.5 1.0 C A:GLU293 4.0 7.2 1.0 CA A:SER294 4.1 7.8 1.0 CG A:PRO292 4.1 12.8 1.0 CG A:LYS297 4.1 22.3 1.0 CE2 A:PHE277 4.2 9.6 1.0 O A:HOH612 4.2 35.4 1.0 CA A:PRO292 4.5 7.2 1.0 O A:HOH566 4.5 34.2 1.0 CD1 A:LEU281 4.6 11.6 1.0 CB A:LYS297 4.7 12.2 1.0 O A:HOH504 4.8 22.3 1.0 OE2 A:GLU278 5.0 33.0 1.0

Chlorine binding site 4 out of 4 in the Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Mouse Viperin Bound to Uridine Triphosphate and S-Adenosylhomocysteine within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl404 b:30.4 occ:1.00 O B:HOH769 2.8 41.3 1.0 NZ B:LYS297 3.1 39.6 1.0 N B:SER294 3.2 8.4 1.0 CB B:SER294 3.7 9.2 1.0 O B:HOH691 3.7 25.7 1.0 OG B:SER294 3.9 11.7 1.0 CB B:PRO292 3.9 15.1 1.0 O B:PRO292 3.9 9.8 1.0 C B:PRO292 4.0 12.5 1.0 CG B:LYS297 4.0 20.1 1.0 CA B:SER294 4.0 8.5 1.0 N B:GLU293 4.0 12.2 1.0 CE2 B:PHE277 4.1 7.8 1.0 O B:HOH616 4.1 35.7 1.0 C B:GLU293 4.1 8.1 1.0 CA B:GLU293 4.1 11.5 1.0 CE B:LYS297 4.2 37.8 1.0 CG B:PRO292 4.2 18.8 1.0 CD1 B:LEU281 4.4 10.3 1.0 CD B:LYS297 4.4 28.0 1.0 O B:HOH524 4.5 30.5 1.0 CA B:PRO292 4.6 9.9 1.0 CB B:LYS297 4.8 11.4 1.0 OE2 B:GLU278 4.8 31.1 1.0 CD2 B:PHE277 4.9 8.0 1.0 O B:HOH618 4.9 31.2 1.0 CZ B:PHE277 5.0 7.4 1.0

M.K.Fenwick, D.Su, M.Dong, H.Lin, S.E.Ealick. Structural Basis of Substrate Selectivity of Viperin. Biochemistry 2020.
ISSN: ISSN 0006-2960
PubMed: 31917549
DOI: 10.1021/ACS.BIOCHEM.9B00741