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Chlorine in PDB 6qef: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
Enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide:
3.4.11.18;
3.4.11.18;
Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide, PDB code: 6qef
was solved by
D.Musil,
T.Heinrich,
M.Lehmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.45 / 1.79 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 88.360, 99.400, 100.600, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.5 / 19.5 |
Other elements in 6qef:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Manganese | (Mn) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
(pdb code 6qef). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide, PDB code: 6qef:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide, PDB code: 6qef:
Chlorine binding site 1 out of 1 in 6qef
Go back to
Chlorine Binding Sites List in 6qef
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide within 5.0Å range:
|
Reference:
T.Heinrich,
J.Seenisamy,
B.Blume,
J.Bomke,
M.Calderini,
U.Eckert,
M.Friese-Hamim,
R.Kohl,
M.Lehmann,
B.Leuthner,
D.Musil,
F.Rohdich,
F.T.Zenke.
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (Metap-2) Inhibitors. J.Med.Chem. V. 62 5025 2019.
ISSN: ISSN 0022-2623
PubMed: 30939017
DOI: 10.1021/ACS.JMEDCHEM.9B00041
Page generated: Mon Jul 29 13:55:50 2024
ISSN: ISSN 0022-2623
PubMed: 30939017
DOI: 10.1021/ACS.JMEDCHEM.9B00041
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