Chlorine in PDB 6qml: UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin

All present enzymatic activity of UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin:
3.4.19.12;

The structure of UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin, PDB code: 6qml was solved by A.G.Murachelli, T.K.Sixma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.30 / 2.10
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	70.290, 81.206, 159.858, 90.00, 90.00, 90.00
R / Rfree (%)	18.4 / 23.3

The structure of UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin also contains other interesting chemical elements:

Bromine	(Br)	4 atoms
Potassium	(K)	5 atoms

The binding sites of Chlorine atom in the UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin (pdb code 6qml). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin, PDB code: 6qml:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl308 b:75.0 occ:1.00 CA A:ASN107 3.7 42.4 1.0 K A:K301 3.8 50.0 1.0 CB A:ASP109 3.9 70.7 1.0 NZ A:LYS110 3.9 72.5 1.0 C A:ASN107 3.9 40.2 1.0 CE A:LYS110 4.0 58.2 1.0 OD2 A:ASP109 4.0 0.3 1.0 CG A:LYS110 4.1 51.3 1.0 O A:ASN106 4.1 38.7 1.0 O A:HOH487 4.2 54.8 1.0 O A:ASN107 4.3 40.8 1.0 N A:ASP109 4.4 52.0 1.0 OD1 A:ASN107 4.4 37.3 1.0 N A:LYS108 4.4 48.1 1.0 CG A:ASP109 4.4 91.0 1.0 N A:ASN107 4.6 39.1 1.0 N A:LYS110 4.6 42.8 1.0 CA A:ASP109 4.6 59.8 1.0 CD A:LYS110 4.7 55.9 1.0 CB A:ASN107 4.7 39.3 1.0 C A:ASN106 4.7 36.8 1.0 CG A:ASN107 4.9 36.2 1.0 O A:HOH455 4.9 45.5 1.0 C A:ASP109 5.0 59.3 1.0

Chlorine binding site 2 out of 2 in the UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of UCHL3 in Complex with Synthetic, K27-Linked Diubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl308 b:65.6 occ:1.00 CB D:ASP109 3.7 58.4 1.0 CE D:LYS110 3.8 54.4 1.0 CA D:ASN107 3.9 35.7 1.0 CG D:LYS110 3.9 51.1 1.0 K D:K301 3.9 48.4 1.0 C D:ASN107 4.0 40.3 1.0 NZ D:LYS110 4.2 60.3 1.0 O D:ASN107 4.2 41.2 1.0 N D:ASP109 4.2 50.0 1.0 N D:LYS110 4.3 45.5 1.0 O D:ASN106 4.4 35.7 1.0 CA D:ASP109 4.4 53.0 1.0 CD D:LYS110 4.4 52.5 1.0 OD1 D:ASN107 4.4 35.8 1.0 N D:LYS108 4.5 44.6 1.0 CG D:ASP109 4.5 73.2 1.0 OD2 D:ASP109 4.6 81.3 1.0 C D:ASP109 4.6 56.0 1.0 CB D:ASN107 4.8 35.2 1.0 N D:ASN107 4.8 34.5 1.0 CB D:LYS110 5.0 46.2 1.0 C D:ASN106 5.0 33.8 1.0

A.G.Murachelli, T.K.Sixma. UCHL3 Is Inhibited By LYS27-Linked Diubiquitin To Be Published.